Flavonoids from Echinacea purpurea

Куркин, В. А.; Akushskaya, A. S.; Авдеева, Е В; Velmyaikina, E. I.; Даева, Е. Д.; Kadentsev, V. I.

doi:10.1134/s1068162011070120

Cited by 17 publications

(8 citation statements)

References 3 publications

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“…Here, one can also consider techniques such as NMR for identification of constituents; the success of such techniques will depend on the ability to isolate the constituents and the concentration of constituents in a botanical product. Echinacea species are known to contain caftaric acid, chicoric acid, chlorogenic acid, butylamides (e.g., DT-IBA), echinacosides, and cynarins; the level and ratio of constituents depends on multiple factors including the species and plant part(s) and extraction process used in the preparation (AHP, 2004;Barnes et al, 2005;Kurkin et al, 2011;USP, 2015). The mass spectrometric data confirmed the presence of caftaric acid, chicoric acid, chlorogenic acid, numerous butylamides, echinacoside, and cynarin isomers along with other phytochemicals (Figure 7, Tables 4 and 5).…”

Section: Discussionmentioning

confidence: 99%

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A strategy for test article selection and phytochemical characterization of Echinacea purpurea extract for safety testing

Waidyanatha

Pierfelice

Cristy

et al. 2020

Food and Chemical Toxicology

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Botanical dietary supplements (BDS) are used around the world for many purported therapeutic properties. The selection of an authentic product and it's phytochemical characterization is critical to generate robust safety data. Because botanicals are complex mixtures with variable quality, identification of a representative product for testing has been challenging. Echinacea is used for its purported immune stimulant properties and was listed as the 2 nd top-selling BDS in 2018. However, there are limited safety data for Echinacea. Hence, the National Toxicology Program (NTP) has selected Echinacea for safety testing using rodent models. Here, we describe selection and comprehensive characterization of an Echinacea purpurea root extract to be used in the NTP testing program. Using non-targeted chemical analyses combined with chemometric analysis, a potential unfinished product (i.e., an extract that serves as source material for finished products) of Echinacea purpurea was selected. The product was then authenticated using chemical and DNA techniques and characterized, including the phytochemical composition. Among numerous constituents identified, caftaric acid, chicoric acid, chlorogenic acid and dodeca-2(E),4(E),8(Z),10(E/Z)-tetraenoic acid isobutylamide made up a small fraction of the extract. Based on these analyses, an approach is proposed for test article selection for Echinacea research which can be adapted to other botanicals.

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Section: Discussionmentioning

confidence: 99%

“…c References for the presence of this compound in Echinacea species: 1) AHP ( 2004) 2) Kurkin et al, (2011) b Only sample 7 was analyzed by LC-MS/MS. c…”

Section: Discussionmentioning

confidence: 99%

A strategy for test article selection and phytochemical characterization of Echinacea purpurea extract for safety testing

Waidyanatha

Pierfelice

Cristy

et al. 2020

Food and Chemical Toxicology

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“…Analyses of the composition of Echinacea extracts revealed that chicoric acid was the dominant component (among the phenylpropanoids) [ 13 ], along with phenolic compounds such as flavonoids [ 14 ], tannins, alkaloids, starch, furochromones, and glycosides [ 15 ], all of them acting as reducing agents and stabilizing agents in the synthesis of nanoparticles [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Phytosynthesis of Biological Active Silver Nanoparticles Using Echinacea purpurea L. Extracts

et al. 2022

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With their phytoconstituents acting as reducing and capping agents, natural extracts can be considered a viable alternative for the obtaining of metallic nanoparticles. The properties of phytosynthesized nanoparticles are dependent upon size and morphology, which, in turn, can be tailored by adjusting different parameters of the phytosynthesis process (such as the extracts’ composition). In the present study, we aimed to evaluate, for the first time in the literature, the influence of the extraction method and extract concentration on the morphological and biological properties (antioxidant and antibacterial activity) of silver nanoparticles phytosynthesized using Echinacea pupurea L. extracts. The obtained results revealed that the use of the low-concentration Echinacea hydro-alcoholic extract obtained via classical temperature extraction led to the development of nanoparticles with the smallest dimensions (less than 10 nm), compared with the use of extracts obtained with higher concentrations and the extract obtained via the microwave method. The developed nanomaterials exhibited enhanced antioxidant effects (determined via the DPPH assay) and antimicrobial properties (against Escherichia coli and Candida albicans), compared with the parent extracts.

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“…Как уже отмечалось, доминирующей группой биологически активных соединений фенольного комплекса водно-спиртовых экстрактов из культур клеток и тканей Echinacea purpurea L. Moench являются фенилпропаноиды -ГКК и их производные, на основе которых синтезируются флавоноиды, кумарины, стильбены, лигнаны и др. Помимо фенилпропаноидов, эхинацея пурпурная содержит такие ценные ФС, как флавоноиды (кверцетин, кемпферол, лютеолин, апигенин, изорамнетин и их различные гликозиды) [33]. Для оценки элиситорной активности ДЭ в нашей работе были проанализированы изменения уровней накопления указанных выше классов ФС в обработанных клетках исследуемых суспензионных культур.…”

Section: результаты и их обсуждениеunclassified

Stimulation of phenolic nature secondary metabolites biosynthesis in Echinacea purpurea L. Moench suspension cell cultures under influence yeast extract elisitors

Nester¹,

Дитченко²

2020

Journal of the Belarusian State University. Biology

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Тhe ability of 50 ‒500 mg / L yeast extract as complex biotic elicitor to induce an increase in the accumulation of secondary phenolic metabolites in Echinacea purpurea L. Moench suspension cell cultures initiated from calli of leaf and root origin was studied. The yeast extract stimulating effect is more pronounced for a weakly aggregated suspension culture of leaf origin compared with a root origin culture of highly aggregated type. The increase of phenylpropanoids (2.5 times) and flavonoids (2.0 times) content in aqueous-alcoholic extracts from leaf culture as a result of 2-day exposure to 100 ‒500 mg/L of yeast extract correlates with their antiradical activity increase in model system for 2,2ʹ-diphenyl-1-picrylhydrazyl radicals inhibition. The exposure of suspension cell cultures of leaf and root origin in the presence of 250 ‒500 mg/L yeast extract leads 2.1‒2.7 and 1.2‒1.3 times increase L-phenylalanine ammonium lyase activity as key enzyme of phenolic compounds biosynthesis.

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Flavonoids from Echinacea purpurea

Cited by 17 publications

References 3 publications

A strategy for test article selection and phytochemical characterization of Echinacea purpurea extract for safety testing

A strategy for test article selection and phytochemical characterization of Echinacea purpurea extract for safety testing

Phytosynthesis of Biological Active Silver Nanoparticles Using Echinacea purpurea L. Extracts

Stimulation of phenolic nature secondary metabolites biosynthesis in Echinacea purpurea L. Moench suspension cell cultures under influence yeast extract elisitors

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