Flavonoids from Seabuckthorn (<i>Hippophae rhamnoides</i> L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

Xia, Chen-Xi; Gao, Alex Xiong; Zhu, Yue; Dong, Tina Ting-Xia; Tsim, Karl Wah-Keung

doi:10.1039/d3fo01332d

Cited by 16 publications

(4 citation statements)

References 63 publications

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“…Tyrosine and tryptophan are typical aromatic amino acids that are metabolized by Lachnospiraceae, which is one of the main microbial pathways in the human gut that produces indole-propionic acid, indole, phenol, and p-cresol [43]. In addition, Lachnospiraceae has been found to be signi cantly associated with attenuating in ammation in obese [44] and CUMS mice [45]. Consistent with previous research, uncultured_f_Lachnospiraceae and unclassi ed_f_Lachnospiraceae were drastically and poorly associated with pro-in ammatory cytokines.…”

Section: Discussionsupporting

confidence: 86%

Evening inulin treatment alleviate anxiety and depression via gut-brain axis: A crucial role for microbiota and amino acids metabolism

Chen,

Hou

et al. 2024

Preprint

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Background Increasing evidence has demonstrated that an imbalance in the microbiota-gut-brain axis exerts an essential effect on the pathophysiology of depressive and anxiety disorders. Our previous research revealed that the timing of inulin administration altered its influence on CUMS-induced anxiety and depression; however, it is still unclear if the gut-brain axis is primarily responsible for these effects. Results Serum metabolomics analysis showed that inulin treatment can alleviate the inflammatory response in CUMS-treated mice and that amino acid metabolic pathways were crucial for its anxiolytic and antidepressant effects. The time of administration seemed to modify the anxiolytic and antidepressant effects of inulin, and inulin intervention in the evening was more pronounced in improving amino acid metabolism and inhibiting the inflammatory response than that of morning inulin treatment. In addition, inulin treatment in the evening significantly reduced serum glucose and insulin levels. The main differential metabolites, including fenofibric acid, 4’-Hydroxyfenoprofen glucuronide and 5-(4-Hydroxybenzyl)thiazolidine-2,4-dione may play important roles for the anxiolytic and antidepressant ability of inulin. Fecal microbiota transplantation confirmed that inulin treatment alleviated CUMS-induced anxiety- and depression-like behaviors via gut-brain axis. Conclusions Our results suggest that inulin administration in the evening is more effective in alleviating the inflammatory response and improving amino acid metabolism. This study provides a new potential link between the microbiota-gut-brain axis and chrono-nutrition, which indicates that a more appropriate administration time results in a better intervention effect.

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Section: Discussionsupporting

confidence: 86%

Evening inulin treatment alleviate anxiety and depression via gut-brain axis: A crucial role for microbiota and amino acids metabolism

Chen,

Hou

et al. 2024

Preprint

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“…As seen with kaempferol and quercetin alone, G. biloba potentiates PI3K/AKT relative to CREB signaling to promote neuroplasticity [287,[289][290][291][292][293]. Hippophae rhamnoides extracts are also rich in quercetin and kaempferol, and they enhanced neuronal differentiation and neurite outgrowth via PI3K/AKT and ERK signaling [294,295]. However, clinical trials have revealed the inconsistent efficacy of G. biloba on cognition and other AD-related parameters [296].…”

Section: Quercetin and Kaempferol In Common Herbsmentioning

confidence: 99%

“…Panax ginseng + + Neuroprotective [175,187,225,278,310] Morenga oleifera + + Memory improvement [300][301][302] Cuscuta chinensis + + Memory improving, Neuroprotective, Hepatoprotective, Immunomodulatory [311] Allium cepa + + Anti-inflammatory [312,313] Hippophae rhamnoides L. + + Anti-inflammatory [294,295] Litchi chinensis + + Neuroprotective [303,314] Prakia roxburghii -+ Neuroprotective [304] Radix astragali…”

Section: Quercetin and Kaempferol In Common Herbsmentioning

confidence: 99%

Polyherbal and Multimodal Treatments: Kaempferol- and Quercetin-Rich Herbs Alleviate Symptoms of Alzheimer’s Disease

Alexander,

Parsaee,

Vasefi

2023

Biology

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Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder impairing cognition and memory in the elderly. This disorder has a complex etiology, including senile plaque and neurofibrillary tangle formation, neuroinflammation, oxidative stress, and damaged neuroplasticity. Current treatment options are limited, so alternative treatments such as herbal medicine could suppress symptoms while slowing cognitive decline. We followed PRISMA guidelines to identify potential herbal treatments, their associated medicinal phytochemicals, and the potential mechanisms of these treatments. Common herbs, including Ginkgo biloba, Camellia sinensis, Glycyrrhiza uralensis, Cyperus rotundus, and Buplerum falcatum, produced promising pre-clinical results. These herbs are rich in kaempferol and quercetin, flavonoids with a polyphenolic structure that facilitate multiple mechanisms of action. These mechanisms include the inhibition of Aβ plaque formation, a reduction in tau hyperphosphorylation, the suppression of oxidative stress, and the modulation of BDNF and PI3K/AKT pathways. Using pre-clinical findings from quercetin research and the comparatively limited data on kaempferol, we proposed that kaempferol ameliorates the neuroinflammatory state, maintains proper cellular function, and restores pro-neuroplastic signaling. In this review, we discuss the anti-AD mechanisms of quercetin and kaempferol and their limitations, and we suggest a potential alternative treatment for AD. Our findings lead us to conclude that a polyherbal kaempferol- and quercetin-rich cocktail could treat AD-related brain damage.

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“…Fruits' intervention did not inhibit the ratio of Firmicutes to Bacteroidetes but reduced the relative abundance of Erysipelotrichaceae, which might be responsible for the anti-obesity effect [50]. Sea buckthorn (Hippophae rhamnoides L.) is rich in flavonoids, which has been reported to have the ability to regulate the gut microbiome by decreasing the abundance of Lactobacillaceae and increasing the abundance of Lachnospiraceae at the family level [84]. Total flavonoids from Chimonanthus nitens Oliv.…”

Section: Flavonoidsmentioning

confidence: 99%

Bioactive Components in Fruit Interact with Gut Microbes

Jin,

Chen,

et al. 2023

Biology

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Fruits contain many bioactive compounds, including polysaccharides, oligosaccharides, polyphenols, anthocyanins, and flavonoids. All of these bioactives in fruit have potentially beneficial effects on gut microbiota and host health. On the one hand, fruit rich in active ingredients can act as substrates to interact with microorganisms and produce metabolites to regulate the gut microbiota. On the other hand, gut microbes could promote health effects in the host by balancing dysbiosis of gut microbiota. We have extensively analyzed significant information on bioactive components in fruits based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Although the deep mechanism of action of bioactive components in fruits on gut microbiota needs further study, these results also provide supportive information on fruits as a source of dietary active ingredients to provide support for the adjunctive role of fruits in disease prevention and treatment.

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Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

Abstract: Seabuckthorn (Hippophae rhamnoides L.), having an enrichment of flavonoids including isorhamnetin, quercetin and kaempferol, is a representative example of “medicine food homology” targeting at several diseases. Major depressive disorders seriously...

Cited by 16 publications

References 63 publications

Evening inulin treatment alleviate anxiety and depression via gut-brain axis: A crucial role for microbiota and amino acids metabolism

Evening inulin treatment alleviate anxiety and depression via gut-brain axis: A crucial role for microbiota and amino acids metabolism

Polyherbal and Multimodal Treatments: Kaempferol- and Quercetin-Rich Herbs Alleviate Symptoms of Alzheimer’s Disease

Bioactive Components in Fruit Interact with Gut Microbes

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