Flavonoids from the aerial part of Vicia subvillosa

Yuldashev, M. P.; Muminova, B. A.; Drenin, A. A.; Ботиров, Э. Х.

doi:10.1007/s10600-007-0058-5

Cited by 12 publications

(10 citation statements)

References 3 publications

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“…of the derivatives at each concentration against both radical species were not significantly different to that of quercetin (p > 0.05). This is with exception to 5b (20 and 40 μM) and 5c (20,40, 60 and 150 μM) against ABTS as well as 5a (200, 400 and 500 μM) and 5c (200, 400 and 500 μM) against DPPH which were determined as significantly different (p < 0.05), and therefore displayed slightly reduced activity to that of quercetin. The radical scavenging activity of the quercetin derivatives 5a-g was then determined (see supplementary material).…”

Section: Abts and Dpph Radical Scavenging Activity Studiesmentioning

confidence: 79%

“…This shows that acylation at the 5-O position resulted in more organic soluble molecules compared to 1 alone. It was also noted that the addition of the acyl groups at the 5-O position had greatly reduced the melting poing of the derivatives (160-189 • C) compared that reported for 1 (313-314 • C) [20]. BnBr, K2CO3, dimethylformamide (DMF), 100 °C, 24 h, 54%; (iii) Et3N, acyl chlorides, 4a 75%, 4b 94%, 4e 88%, 4f 88%; (iv) Pd(OH)2/C or Pd/C, H2, tetrahydrofuran (THF), r.t., 4 d, 5a 46%, 5b 73%, 5c 56% over 2 steps, 5d 60% over 2 steps, 5e 70%, 5f 55%, 5g 88% over two steps.…”

Section: Syntheses Of 5-o-acyl Quercetin Derivativesmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

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Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Leung

Fedrizzi

et al. 2021

Molecules

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Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity.

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Section: Abts and Dpph Radical Scavenging Activity Studiesmentioning

confidence: 79%

Section: Syntheses Of 5-o-acyl Quercetin Derivativesmentioning

confidence: 82%

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Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Leung

Fedrizzi

et al. 2021

Molecules

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“…Based on comparison with authentic kaempferol by TCL analysis in the chloroform-ethyl acetate sol vent system (6 : 3 : 1), the spectral data and physico chemical properties compound 1 was determined as 3,5,7,4' tetrahydroxyflavon (kaempferol) [12,13]. Kaempferol from Equisetum silvaticum L. was isolated for the first time.…”

Section: Resultsmentioning

confidence: 99%

Kaempferol and its glycosides from Equisetum silvaticum L. from the Khanty-Mansi autonomous area

Bonacheva

Ботиров

2014

Russ J Bioorg Chem

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“…koreanum Nakai.The known compounds were identified as icarisideII (6) [10], afzelin (7) [ 11],q uercitrin (8) [ 12], morelosin (9) [ 13], chrysin( 10) [ 14], apigenin (11) [ 15], luteolin (12) [15], and quercetin (13) (Fig.1) [15]. Among them, compounds 9 and 10 were isolated from the genus Epimedium for the first time.Compounds 2, 7, 8, 11,and 13 were evaluatedf or anti-HIV-1 activity,a nd among them, compound 11 showed moderate anti-HIV-1 activity with an EC 50 value of 12.8 AE 3.27 mg/ml.…”

mentioning

confidence: 99%

Flavonoids Isolated from Heat‐Processed Epimedium koreanum and Their Anti‐HIV‐1 Activities

Zhou

Chen

et al. 2015

Helvetica Chimica Acta

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Systematic phytochemical investigation on heat-processed Epimedium koreanum led to the isolation of 13 flavonoids, including five new prenyl-flavonol glycosides,k oreanosidesA-E (1 -5,r esp.).T heir structures were elucidated on the basis of detailed analysis of the 1D-and 2D-NMR spectroscopic data and chemical reactions.A pigenin (11)e xhibited moderate anti-HIV-1 activity with an EC 50 value of 12.8 AE 3.27 mg/ml.Introduction. -Herba epimedii, also named Horny Goat Weed or YinY ang Huo, has been used in Tr aditional Chinese Medicine (TCM)a sat onic, antirheumatic, and aphrodisiac for more than 2000y ears.T he aerialp arts of Epimediumk oreanum (Berberidaceae), togetherwith threeother species, E. brevicornu, E. sagittatum,and E. pubescens,w ere officially adopted in the Chinese Pharmacopoeia [1].P revious chemical and pharmacological investigations on epimedii foundt hat the major bioactivec onstituents are prenyl-flavonoids,w hich exhibit aw ide range of biological activities,s ucha sa nti-osteoporosis,a ndrogenic, anti-inflammatory,a nd anticancer effects [2]. EpimedinC ,i cariin, and baohuoside I, threem ain flavonoids in the crude herb,h ave been used as markers for quality evaluationb yHPLC/UV[ 1] [3].Traditionally,h erba epimedii was processed by heating with sheepf at to enhance hormonal and anti-inflammatory effects [4][5].R eportedly,H PLC analysis showed that the content of prenyl-flavonoid bisdesmosides (such as icarrin and, epimedins A-C) decreased in the heat-processed form, whereas that of monodesmosides (such as baohuoside I) increased [6]. In an in vitro cultured Caco-2 cell model, the absorption and metabolism of the monoglycosideb aohuosideIwas greatert han those of bisdesmoside prenyl-flavonoidsw ith two or more sugar moieties [7].However, no systematic phytochemical study on heat-processed epimedii has been reported.A sacontinuation of our research on medicinal plantsi nt he genus Epimedium [8][9], 13 flavonoids,i ncludingf ive new prenyl-flavonol glycosides, koreanosides A-E( 1 -5,r esp.; Fig. 1), were isolated from heat-processed E.

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Flavonoids from the aerial part of Vicia subvillosa

Cited by 12 publications

References 3 publications

Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Kaempferol and its glycosides from Equisetum silvaticum L. from the Khanty-Mansi autonomous area

Flavonoids Isolated from Heat‐Processed Epimedium koreanum and Their Anti‐HIV‐1 Activities

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