Flavonoids in Lu’an GuaPian tea as potential inhibitors of TMA‐lyase in acute myocardial infarction

Fang, Hua; Zhou, Peng; Bao, Guan‐Hu; Ling, Tie-Jun

doi:10.1111/jfbc.14110

Cited by 7 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hu et al [152] reported that TMAOinduced vascular dysfunction and hepatic injury were significantly attenuated by the administration of tartary buckwheat flavonoids (consisting of rutin and quercetin) to TMAfed mice for 8 weeks at 400 or 800 mg/kg BW. In addition, quercetin 3-ramnosylgalactoside was suggested to reduce the production of TMAO from TMA by acting as a potential inhibitor of TMA-lyase [153]. The possible functions of quercetin glycosides in the large intestine are summarized in Figure 7.…”

Section: Modulation Of Gut Microbiota Profilesmentioning

confidence: 99%

Potential Role of Quercetin Glycosides as Anti-Atherosclerotic Food-Derived Factors for Human Health

Terao

2023

Antioxidants

View full text Add to dashboard Cite

Quercetin is a monomeric polyphenol of plant origin that belongs to the flavonol-type flavonoid subclass. Extensive studies using cultured cells and experimental model animals have demonstrated the anti-atherosclerotic effects of dietary quercetin in relation to the prevention of cardiovascular disease (CVD). As quercetin is exclusively present in plant-based foods in the form of glycosides, this review focuses on the bioavailability and bioefficacy of quercetin glycosides in relation to vascular health effects. Some glucose-bound glycosides are absorbed from the small intestine after glucuronide/sulfate conjugation. Both conjugated metabolites and deconjugated quercetin aglycones formed by plasma β-glucuronidase activity act as food-derived anti-atherogenic factors by exerting antioxidant, anti-inflammatory, and plasma low-density lipoprotein cholesterol-lowering effects. However, most quercetin glycosides reach the large intestine, where they are subject to gut microbiota-dependent catabolism resulting in deglycosylated aglycone and chain-scission products. These catabolites also affect vascular health after transfer into the circulation. Furthermore, quercetin glycosides may improve gut microbiota profiles. A variety of human cohort studies and intervention studies support the idea that the intake of quercetin glycoside-rich plant foods such as onion helps to prevent CVD. Thus, quercetin glycoside-rich foods offer potential benefits in terms of cardiovascular health and possible clinical applications.

show abstract

Section: Modulation Of Gut Microbiota Profilesmentioning

confidence: 99%

Potential Role of Quercetin Glycosides as Anti-Atherosclerotic Food-Derived Factors for Human Health

Terao

2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Acute myocardial infarction (AMI) is the main cause of death because of CHD, and its pathogenesis is closely related to free radicals, ROS, calcium overload, mitochondrial dysfunction, inflammation, and neutrophil-mediated vascular injury (Jung et al, 2022). Flavonoids have a good effect on the prevention of AMI (Hua et al, 2022).…”

Section: Acute Myocardial Infarctionmentioning

confidence: 99%

Liquiritin: A natural flavonoid with potential cardiovascular protection

Zhou,

Peng,

Zhou

2024

Ital. J. Food Sci.

View full text Add to dashboard Cite

Liquiritin is a flavonoid glycoside extracted from traditional Chinese medicine, Radix et Rhizoma Glycyrrhizae. The provide evidence has found that liquiritin has been found to be beneficial to cardiovascular disease. Inflammation and oxidation play key roles in cardiovascular diseases. In this review, the natural sources, biosynthesis, pharmacology and molecular docking of liquiritin were reviewed for the first time. Additionally, we have highlighted the target prediction of liquiritin. Docking results displayed that the three targets with the largest difference in VINA scores were TLR4, Keap-1 and AMPK, which suggested that liquiritin was likely to act on TLR4, Keap-1 and AMPK. Liquiritin will provide theoretical basis for future development and research in cardiovascular diseases.

show abstract

“…This provides direction for the development of new biologics or dietary interventions. Secondely, studies have shown that gut microbiota remodeling through certain interventions, such as Lactobacillus johnsonii, dapagliflozin, and flavonoids, can result in enhanced cardiac function after AMI (253)(254)(255). SCFAs have been found to improve cardiomyocyte function and heart contractility (244,256).…”

Section: Microbiomicsmentioning

confidence: 99%

From multi-omics approaches to personalized medicine in myocardial infarction

Zhan,

Tang,

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe complications such as arrhythmia, cardiac rupture, heart failure, and sudden death. Despite being a research hotspot, the etiological mechanism of MI remains unclear. The emergence and widespread use of omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and other omics, have provided new opportunities for exploring the molecular mechanism of MI and identifying a large number of disease biomarkers. However, a single-omics approach has limitations in understanding the complex biological pathways of diseases. The multi-omics approach can reveal the interaction network among molecules at various levels and overcome the limitations of the single-omics approaches. This review focuses on the omics studies of MI, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and other omics. The exploration extended into the domain of multi-omics integrative analysis, accompanied by a compilation of diverse online resources, databases, and tools conducive to these investigations. Additionally, we discussed the role and prospects of multi-omics approaches in personalized medicine, highlighting the potential for improving diagnosis, treatment, and prognosis of MI.

show abstract

Flavonoids in Lu’an GuaPian tea as potential inhibitors of TMA‐lyase in acute myocardial infarction

Cited by 7 publications

References 48 publications

Potential Role of Quercetin Glycosides as Anti-Atherosclerotic Food-Derived Factors for Human Health

Potential Role of Quercetin Glycosides as Anti-Atherosclerotic Food-Derived Factors for Human Health

Liquiritin: A natural flavonoid with potential cardiovascular protection

From multi-omics approaches to personalized medicine in myocardial infarction

Contact Info

Product

Resources

About