2024
DOI: 10.21203/rs.3.rs-4806818/v1
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Flavonoids of Euphorbia hirta inhibit inflammatory mechanisms via Nrf2 and NF-κB pathways

Xiaolin Bai,
Lijun Li,
Yuning Wu
et al.

Abstract: Euphorbia hirta has anti-inflammatory effects in traditional medicine, but its anti-inflammatory mechanism has not been explored at the cellular and molecular levels. To this end, the main active components of the 65% and 95% ethanol extracts of Euphorbia hirta were first identified by UPLC-Q-TOF/MS. The potential targets and signaling pathway of Euphorbia hirta were identified through network pharmacology, followed by subsequent experimental validation using lipopolysaccharide (LPS)-induced inflammation model… Show more

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