Flavonoids of Plants from the Genus Tamarix

Umbetova, A. K.; Choudhary, M. Iqbal; Султанова, Н. А.; Burasheva, G. Sh.; Abilov, Zharylkasyn A.

doi:10.1007/s10600-006-0023-8

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…The chemical investigation of various Tamarix species was reported. Gallic acid, flavones, and flavonols were among the polyphenols found in this study that were recognized as compounds that had previously been found in other species of Tamarix [ 34 , 95 ]. For example, a study on the alcohol-soluble fraction of an aqueous extract of T. nilotica aerial parts collected from Egypt and Saudi Arabia was discussed by Sekkien A. et al 2018 [ 30 ].…”

Section: Discussionsupporting

confidence: 56%

Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers

Fayed

Bakr

Yosri

et al. 2023

BMC Complement Med Ther

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Background Cancer represents one of the biggest healthcare issues confronting humans and one of the big challenges for scientists in trials to dig into our nature for new remedies or to develop old ones with fewer side effects. Halophytes are widely distributed worldwide in areas of harsh conditions in dunes, and inland deserts, where, to cope with those conditions they synthesize important secondary metabolites highly valued in the medical field. Several Tamarix species are halophytic including T.nilotica which is native to Egypt, with a long history in its tradition, found in its papyri and in folk medicine to treat various ailments. Methods LC–LTQ–MS–MS analysis and 1H-NMR were used to identify the main phytoconstituents in the n- butanol fraction of T.nilotica flowers. The extract was tested in vitro for its cytotoxic effect against breast (MCF-7) and liver cell carcinoma (Huh-7) using SRB assay. Results T.nilotica n-butanol fraction of the flowers was found to be rich in phenolic content, where, LC–LTQ–MS–MS allowed the tentative identification of thirty-nine metabolites, based on the exact mass, the observed spectra fragmentation patterns, and the literature data, varying between tannins, phenolic acids, and flavonoids. 1H-NMR confirmed the classes tentatively identified. The in-vitro evaluation of the n-butanol fraction showed lower activity on MCF-7 cell lines with IC50 > 100 µg/mL, while the higher promising effect was against Huh-7 cell lines with an IC50= 37 µg/mL. Conclusion Our study suggested that T.nilotica flowers' n-butanol fraction is representing a promising cytotoxic candidate against liver cell carcinoma having potential phytoconstituents with variable targets and signaling pathways.

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Section: Discussionsupporting

confidence: 56%

Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers

Fayed

Bakr

Yosri

et al. 2023

BMC Complement Med Ther

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“…Regarding the other main polyphenolics, isorhamnetin was reported to have been identified from T. hispida , T. elongata and T. laxa which were all collected from southern Kazakhstan [11,14]. Quercetin was a common compound in the Tamarix species and had been identified by several researchers [5,8,10,11,15]. Compared to the results of this work, other researchers obtained different polyphenolic compounds from Tamarix .…”

Section: Resultsmentioning

confidence: 50%

“…Flavonoids, which are one group of polyphenolics, are secondary metabolites in plants and act as antioxidants [6]. Many types of polyphenols, such as flavonoids and phenolic acids, were reported in Tamarix species [1,2,7,8,9,10,11]. In this work, the TPC of T. ramosissima bark extract was 323.45 mg gallic acid equivalent (GAE)/g, and the TFC was 87.32 quercetin equivalent (QE)/g.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 13 polyphenolic compounds were identified and, for the first time, hispidulin and cirsimaritin were isolated from the genus Tamarix : they are active ingredients in a number of traditional Chinese herbs [12,13]. Regarding the other main polyphenolics, isorhamnetin was reported to have been identified from T. hispida , T. elongata and T. laxa which were all collected from southern Kazakhstan [11,14]. Quercetin was a common compound in the Tamarix species and had been identified by several researchers [5,8,10,11,15].…”

Section: Resultsmentioning

confidence: 99%

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Isorhamnetin, Hispidulin, and Cirsimaritin Identified in Tamarix ramosissima Barks from Southern Xinjiang and Their Antioxidant and Antimicrobial Activities

et al. 2019

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As a natural potential resource, Tamarix ramosissima has been widely used as barbecue skewers for a good taste and unique flavor. The polyphenolics in the branch bark play a key role in the quality improvement. The purposes of the present work were to explore the polyphenolic composition of T. ramosissima bark extract and assess their potential antioxidant and antimicrobial activities. Hispidulin and cirsimaritin from T. ramosissima bark extract were first identified in the Tamarix genus reported with UPLC-MS analysis. Isorhamnetin (36.91 μg/mg extract), hispidulin (28.79 μg/mg extract) and cirsimaritin (13.35 μg/mg extract) are rich in the bark extract. The extract exhibited promising antioxidant activity with IC50 values of 117.05 μg/mL for 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 151.57 μg/mL for hydroxyl radical scavenging activities, as well as excellent reducing power with an EC50 of 93.77 μg/mL. The bark extract showed appreciable antibacterial properties against foodborne pathogens. Listeria monocytogenes was the most sensitive microorganism with the lowest minimum inhibitory concentration (MIC) value of 5 mg/mL and minimum bactericidal concentration (MBC) value of 10 mg/mL followed by S. castellani and S. aureus among the tested bacteria. The T. ramosissima bark extract showed significantly stronger inhibitory activity against Gram-positive than Gram-negative bacteria. Nevertheless, this extract failed to show any activity against tested fungi. Overall, these results suggested that T. ramosissima shows potential in improving food quality due to its highly efficacious antioxidant and antibacterial properties.

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“…Their structures were elucidated by chromatography; alkaline degradation; acetylation; methylation; UV, IR, and PMR spectroscopy; and melting point [3][4][5][6][7].…”

mentioning

confidence: 99%

Flavonoids from leaves of Pyrus communis, Malus sylvestris, and Malus domestica

Кисличенко

Novosel

2007

Chem Nat Compd

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Flavonoids form one of the most common groups of phenolic compounds and are widely distributed in the plant world. Hydroxyls in their molecules are responsible for their antioxidant activity, which is considered one of the required properties of drugs for treating such diseases as cancer, atherosclerosis, hypertension, infarct, etc. Flavonoids have a variety of effects on the human organism. They exhibit capillary strengthening, antioxidant, antiradiation, antitumor, anti-inflammatory, antiatherosclerotic, spasmolytic, hypotensive, estrogenic, and bactericidal activities. The main property of these compounds is their low toxicity and more often the lack of it [1, 2].We investigated leaves of common pear Pyrus communis L., wild apple Malus sylvestris L., and domestic apple M. domestica Borkh. varieties Antonovka, Glory, and Whitesap, which are widely used in folk medicine to treat various pathologies. The goal of our work was to isolate and identify flavonoids from these types of raw material [2].Ground and air-dried raw material was extracted with ethanol (50%) in a 1:10 (material:extractant) ratio. The aqueous alcohol extracts were combined and evaporated in vacuo to an aqueous residue. The resinous precipitate that formed on standing contained chlorophyll and was removed. The aqueous solution was treated successively with CHCl 3 , ethylacetate, and butanol. The ethylacetate and butanol fractions were evaporated to dryness and chromatographed over a polyamide column (d, 1.5; h, 50 cm) with elution by CHCl 3 and a CHCl 3 :EtOH mixture with a gradually increasing concentration of the latter to 20%. Thus, we isolated 18 compounds of flavonoid nature [3].The structures of the isolated compounds were elucidated using physicochemical, chemical, and biochemical analytical methods (PC and TLC; UV, IR, and PMR spectroscopy; optical activity; melting points; acid and enzymatic hydrolysis) [3].The products from acid hydrolysis of compound 2 contained according to chromatographic and physicochemical methods (acetylation, methylation, alkaline degradation, melting point, direct and differential UV spectroscopy using ionizing and complexing reagents) the aglycon phloretin; 6, apigenin; 8, luteolin; 10, kaempferol; and 12-16, quercetin. Compound 16 contained glucose and rhamnose; 2, 6, 8, 10, and 14, glucose; 12, galactose; 13, rhamnose; and 15, arabinose. The structures of the carbohydate substituents were elucidated using enzymatic hydrolysis by rhamnodiastase and grapevine snail enzyme.Acid hydrolysis of 1, 3, 4, 5, 7, 9, 11, 17, and 18 enabled them to be assigned as flavonoid aglycons. Their structures were elucidated by chromatography; alkaline degradation; acetylation; methylation; UV, IR, and PMR spectroscopy; and melting point [3][4][5][6][7].Thus, the investigations of the compounds isolated from leaves of pear and apple varieties identified them as the following. 1, C 15 H 14 O 5 , mp 257°C, λ max 225, 286 nm; 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone or phloretin; 2, C 21 H 24 O 10 , mp 170-171°C, λ...

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Flavonoids of Plants from the Genus Tamarix

Cited by 9 publications

References 8 publications

Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers

Chemical profiling and cytotoxic potential of the n-butanol fraction of Tamarix nilotica flowers

Isorhamnetin, Hispidulin, and Cirsimaritin Identified in Tamarix ramosissima Barks from Southern Xinjiang and Their Antioxidant and Antimicrobial Activities

Flavonoids from leaves of Pyrus communis, Malus sylvestris, and Malus domestica

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