Flavonoids of the epigeal part ofRhodiola rosea. II. Structures of new glycosides of herbacetin and of gossypetin

Zapesochnaya, G. G.; Куркин, В. А.; Shchavlinskii, A. N.

doi:10.1007/bf00579139

Cited by 20 publications

(22 citation statements)

References 17 publications

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“…Compounds 162‐201 are kaempferol‐type flavonoles. Among them, Compounds 162 , 163 , 164 , 165 ‐ 167 , 168 , 169 , 171‐172 , 173 , 174 , 176 , 182‐183 , 184 , 186 , 188 , 189 , 194 , 195 , 197 , 198 , 199 , and 201 have been found in R. crenulata ; Compounds 163 , 164 , 170 , 171 , 173 , 174 , 177 , 178 , 179 , 181 , 187 , 189 , 190‐191 , 193 , 195 , and 196 have been found in R. rosea ; Compounds 163 , 168 , 171‐172 , 173 , 174 , 179 , 180 , 185‐186 , 189 , 192 , 194 , 198 , and 200 are isolated from R. sachalinensis ; Compounds 163 and 174 are from R. sacra ; Compounds 163 and 189 are isolated from R. quadrifida ; Compounds 163 , 166 , 167 , 173 , 174 , 175 , 188 , and 190 are found in R. dumulosa ...…”

Section: Chemistry and Quality Controlmentioning

confidence: 99%

“…These compounds could be used as potential markers to distinguish R. crenulata and R. rosea with other species. Besides, rhodioflavonoside (Compound 212) is a glycoside coshared between R. rosea and R. quadrifida, 4,71,72,91 while rhodiolgidin (Compound 214) is coexisted in R. crenulata and R. rosea 53,54,114,135. There are three other flavonoles found in R. crenulata, namely crenulatin A (Compound 215), crenulatin B (Compound 216),99 and rhodiolin (Compound 217),56,63,66,87,104,121,126,134 respectively.…”

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confidence: 99%

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Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Tao

Cao

et al. 2019

Medicinal Research Reviews

113

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Rhodiola species, belonging to the family Crassulaceae, have long been used as an adaptogen, tonic, antidepressant, and antistress medicine or functional food in Asia and Europe. Due to the valuable application, the growing demand of Rhodiola species has led to a rapid decrease in resource content. This review aims to summarize the integrated research progress of seven mainstream Rhodiola species. We first outline both traditional and current use of Rhodiola for the treatment of various diseases. A detailed summary and comparison of chemical, pharmacological, toxicological, and clinical studies of various Rhodiola species highlight recent scientific advances and gaps, which gives insights into the understanding of Rhodiola application and would be helpful to improve the situation of biological resources and diversities of Rhodiola plants.

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Section: Chemistry and Quality Controlmentioning

confidence: 99%

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confidence: 99%

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Tao

Cao

et al. 2019

Medicinal Research Reviews

113

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“…As for the compounds, gossypetin-7-Ol-rhamnopyranoside (1) and rhodioflavonoside (2), both are flavonoid glycosides. Gossypetin-7-O-lrhamnopyranoside (1) was isolated in 1985 (Zapesochnaya et al, 1985) form R. rosea. Rhodioflavonoside (2) was isolated in 1996 (Yoshikawa et al, 1996) form R. quadrifida.…”

Section: Discussionmentioning

confidence: 99%

“…Repeated column chromatography followed by crystallization and preparative TLC afforded the isolation of five compounds: gossypetin-7-O-l-rhamnopyranoside (1), rhodioflavonoside (2), gallic acid (3), trans-phydroxycinnamic acid (4) and p-tyrosol (5). Their structures were identified by 1 H and 13 C NMR data, MS spectra and comparison with those reported in the literature (Zapesochnaya et al, 1985;Yoshikawa et al, 1996;Fan et al, 2001;Yu et al, 1993).…”

Section: Extraction Ofmentioning

confidence: 99%

Bioactive compounds fromRhodiola rosea (Crassulaceae)

Ming¹,

Hillhouse²,

Guns³

et al. 2005

Phytother. Res.

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The methanol extract of the underground part of Rhodiola rosea was found to show inhibitory activity against Staphylococcus aureus. Bioactivity-guided fractionation of a 95% ethanol extract from the stems of R. rosea led to the isolation of five compounds: gossypetin-7-O-L-rhamnopyranoside (1), rhodioflavonoside (2), gallic acid (3), trans-p-hydroxycinnamic acid (4) and p-tyrosol (5). Their structures were elucidated by UV, IR, MS and NMR data, as well as by comparison with those of the literature. Compounds 1 and 2 were evaluated for their antibacterial and antiprostate cancer cell activities. Compounds 1 and 2 exhibited activity against Staphylococcus aureus with minimum inhibitory concentrations of 50 microg/mL and 100 microg/mL, respectively. Cytotoxicity studies of 1 and 2 also displayed activity against the prostate cancer cell line with IC(50) values of 50 microg/mL and 80 microg/mL, respectively.

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“…Six different groups of chemical components with pharmaceutical interest could be found in the roots and rhizomes: (1) phenylpropanoids—alcohol derivatives of the cinnamon acid and glycosides like rosavin (2.1%) [33], rosin and rosarin (which are classified under the general name of “rosavins”) [30, 32, 34–36]; (2) phenylethanoids—salidroside (rhodioloside) (0.8%), p -tyrosol [37–42]; (3) flavonoids—including rodiolin, rodionin, rodiosin, acetylrodalgin, tricin [32, 34, 43], and tannins 16–18% [44]; (4) monoterpenes, including rosiridol and rosidarin; (5) triterpenes, such as daucosterol and betasitosterol; (6) phenolic acids such as chlorogenic, hydroxycinnamic, gallic acids [29] and essential oils [35, 45, 46]. All these substances determine the specificity of the Rhodiola extracts.…”

Section: Rhodiola Rosea L: Importance and Characterizationmentioning

confidence: 99%

The Role of Biotechnology for Conservation and Biologically Active Substances Production ofRhodiola rosea: Endangered Medicinal Species

Tasheva

Kosturkova

2012

The Scientific World Journal

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At present, more than 50 000 plant species are used in phytotherapy and medicine. About 2/3 of them are harvested from nature leading to local extinction of many species or degradation of their habitats. Biotechnological methods offer possibilities not only for faster cloning and conservation of the genotype of the plants but for modification of their gene information, regulation, and expression for production of valuable substances in higher amounts or with better properties. Rhodiola rosea is an endangered medicinal species with limited distribution. It has outstanding importance for pharmaceutical industry for prevention and cure of cancer, heart and nervous system diseases, and so forth. Despite the great interest in golden root and the wide investigations in the area of phytochemistry, plant biotechnology remained less endeavoured and exploited. The paper presents research on initiation of in vitro cultures in Rhodiola rosea and some other Rhodiola species. Achievements in induction of organogenic and callus cultures, regeneration, and micropropagation varied but were a good basis for alternative in vitro synthesis of the desired metabolites and for the development of efficient systems for micropropagation for conservation of the species.

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Flavonoids of the epigeal part ofRhodiola rosea. II. Structures of new glycosides of herbacetin and of gossypetin

Cited by 20 publications

References 17 publications

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study

Bioactive compounds fromRhodiola rosea (Crassulaceae)

The Role of Biotechnology for Conservation and Biologically Active Substances Production ofRhodiola rosea: Endangered Medicinal Species

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