Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion

Tavsan, Zehra; Kayalı, Hülya Ayar

doi:10.1016/j.biopha.2019.109004

Cited by 155 publications

(99 citation statements)

References 53 publications

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“…Furthermore, the changes induced by apigenin in healthy ovarian cells, observed in the present experiments, explain its ability to promote ovarian functions during polycystic ovarian syndrome [ 51 ] and ischemia-reperfusion injury [ 52 ]. Moreover, the ability of apigenin to induce apoptosis and to reduce the viability of cancer cells, observed previously [ 50 ], but not those in healthy ovarian cells (in our experiments), sustains a potential applicability of apigenin for the selective suppression of cancer and for the support of healthy cells in the ovary.…”

Section: Discussionsupporting

confidence: 88%

“…These doses correspond to those of CuNPs that can be ingested and that have been applied in previous animal experiments, both in vivo and in vitro [ 20 , 58 , 59 , 60 , 61 ]. The dose of the plant additives was selected on the basis of the doses used in the corresponding previous in vitro experiments [ 41 , 43 , 45 , 49 , 50 ]. These substances were dissolved in the culture medium just before their addition to the cells.…”

Section: Methodsmentioning

confidence: 99%

“…Rutin was able to prevent also the symptoms of polycystic ovarian syndrome [ 47 ]. Another flavonoid-type phytoestrogen, apigenin, is able to suppress proliferation and viability, and to promote oxidative stress and apoptosis in non-ovarian [ 48 , 49 ] and ovarian [ 50 ] cancer cells. It can restore ovarian folliculogenesis, ovulation, and steroidogenesis during polycystic ovarian syndrome [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

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Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

et al. 2020

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The application of nanoparticles has experienced a vertiginous growth, but their interaction with food and medicinal plants in organisms, especially in the control of reproduction, remains unresolved. We examined the influence of copper nanoparticles supported on titania (CuNPs/TiO2), plant extracts (buckwheat (Fagopyrum esculentum) and vitex (Vitex agnus-castus)), phytochemicals (rutin and apigenin), and their combination with CuNPs/TiO2 on ovarian cell functions, using cultured porcine ovarian granulosa cells. Cell viability, proliferation (PCNA accumulation), apoptosis (accumulation of bax), and hormones release (progesterone, testosterone, and 17β-estradiol) were analyzed by the Trypan blue test, quantitative immunocytochemistry, and ELISA, respectively. CuNPs/TiO2 increased cell viability, proliferation, apoptosis, and testosterone but not progesterone release, and reduced the 17β-estradiol output. Plant extracts and components have similar stimulatory action on ovarian cell functions as CuNPs/TiO2, but abated the majority of the CuNPs/TiO2 effects. This study concludes that (1) CuNPs/TiO2 can directly stimulate ovarian cell functions, promoting ovarian cell proliferation, apoptosis, turnover, viability, and steroid hormones release; (2) the plants buckwheat and vitex, as well as rutin and apigenin, can promote some of these ovarian functions too; and (3) these plant additives mitigate the CuNPs/TiO2’s activity, something that must be considered when applied together.

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Section: Discussionsupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

et al. 2020

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“…Furthermore, kaempferol exerted cytotoxic effects on rat hepatocellular carcinoma cells via ROS-mediated mitochondrial targeting [81]. The anticancer activities of flavones apigenin and luteolin in ovarian cancer cell lines (A2780, OVCAR-3 and SKOV-3) were also related to the changes in ROS signaling, as well as to the promotion of apoptosis [82,83]. Moreover, apigenin activated apoptosis also in human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16 and HPV 18-positive), and C33A (HPV-negative) cells due to increased ROS generation and launched mitochondrial apoptotic pathways [84].…”

Section: Flavonoids In Oxidative Stressmentioning

confidence: 99%

Flavonoids as Anticancer Agents

et al. 2020

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Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. This article reviews the biochemical properties and bioavailability of flavonoids, their anticancer activity and its mechanisms of action.

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“…For instance, cotreatment with antioxidant supplements that attenuate cisplatin-mediated nephrotoxicity through Nrf2 signaling has been investigated [108]. Moreover, plant-derived phytochemicals such as flavonoids and carotenoids that act as both antioxidants and prooxidants to improve the therapeutic effects and to reduce the cytotoxic effect have been reported [109][110][111].…”

Section: Application Of Ros Induction For Anticancer Strategiesmentioning

confidence: 99%

Understanding of ROS-Inducing Strategy in Anticancer Therapy

Kim

Seo

2019

Oxidative Medicine and Cellular Longevity

301

193

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Redox homeostasis is essential for the maintenance of diverse cellular processes. Cancer cells have higher levels of reactive oxygen species (ROS) than normal cells as a result of hypermetabolism, but the redox balance is maintained in cancer cells due to their marked antioxidant capacity. Recently, anticancer therapies that induce oxidative stress by increasing ROS and/or inhibiting antioxidant processes have received significant attention. The acceleration of accumulative ROS disrupts redox homeostasis and causes severe damage in cancer cells. In this review, we describe ROS-inducing cancer therapy and the anticancer mechanism employed by prooxidative agents. To understand the comprehensive biological response to certain prooxidative anticancer drugs such as 2-methoxyestradiol, buthionine sulfoximine, cisplatin, doxorubicin, imexon, and motexafin gadolinium, we propose and visualize the drug-gene, drug-cell process, and drug-disease interactions involved in oxidative stress induction and antioxidant process inhibition as well as specific side effects of these drugs using pathway analysis with a big data-based text-mining approach. Our review will be helpful to improve the therapeutic effects of anticancer drugs by providing information about biological changes that occur in response to prooxidants. For future directions, there is still a need for pharmacogenomic studies on prooxidative agents as well as the molecular mechanisms underlying the effects of the prooxidants and/or antioxidant-inhibitor agents for effective anticancer therapy through selective killing of cancer cells.

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Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion

Cited by 155 publications

References 53 publications

Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

Flavonoids as Anticancer Agents

Understanding of ROS-Inducing Strategy in Anticancer Therapy

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