Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression

Santos, Balbino Lino dos; Oliveira, Mona N.; Coelho, Paulo Lucas Cerqueira; Pitanga, Bruno Penas Seara; Silva, Alessandra B. da; Barros, Turíbio; Silva, Victor Diógenes A.; Costa, Maria de Fátima Dias; El-Bachá, Ramon dos Santos; Tardy, M.; Chneiweiss, Hervé; Junier, Marie‐Pierre; Moura‐Neto, Vivaldo; Costa, Sílvia Lima

doi:10.1016/j.cbi.2015.07.014

Cited by 74 publications

(71 citation statements)

References 29 publications

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“…[29] Flavonoids (rutin, quercetin, apigenin, kaempferol and others) induced a delay in cell migration, related to a decrease of MMP-2. [30] Tomatidine, the aglycone of the glycoalkaloid tomatine, also reduced cell invasion and MMP-2/9 expression. [31] Considering the chemosensitizing effect, Jiang et al showed that a quinoid diterpene, cryptotanshinone (isolated from the roots of Salvia miltiorrhiza) sensitized ovarian Chem.…”

Section: Discussionmentioning

confidence: 96%

“…For instance, berberine, an isoquinoline alkaloid isolated from medicinal herbs, inhibited the degradative action of extracellular MMP‐2/9 . Flavonoids (rutin, quercetin, apigenin, kaempferol and others) induced a delay in cell migration, related to a decrease of MMP‐2 . Tomatidine, the aglycone of the glycoalkaloid tomatine, also reduced cell invasion and MMP‐2/9 expression .…”

Section: Discussionmentioning

confidence: 99%

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Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Miranda

Mondal

Singh

et al. 2019

Chemistry & Biodiversity

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Cernumidine (CER) is a guanidinic alkaloid isolated from Solanum cernuum leaves. In this work, we investigated the cytotoxicity, chemosensitizing effect of cernumidine to cisplatin (cDDP) and the possible mechanism of action of the combination on bladder cancer cells. Cernumidine showed cytotoxicity and could sensitize bladder cancer cells to cisplatin. The combination of CER+cDDP inhibited cell migration on T24 cells. CER+cDDP down‐regulated MMP‐2/9 and p‐ERK1/2, while it increased EGFR activity corroborating the observed cell migration inhibition. Down‐regulation of Bcl‐2 and up‐regulation pro‐apoptotic Bax and further depletion of the mitochondrial membrane potential (ΔΨm) indicates that mitochondria play a central role in the combination treatment inducing the mitochondrial signaling pathway of apoptosis in T24 cells. Our data showed that the alkaloid cernumidine is worthy of further studies as a chemosensitizing agent to be used in complementary chemotherapy.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Miranda

Mondal

Singh

et al. 2019

Chemistry & Biodiversity

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“…Recent studies have demonstrated that apigegin may be a cancer chemopreventive agent (Shukla & Gupta, ), and the apigenin‐rich diet also has the lower risks of breast cancer in women (Yap, ) and prostate cancer in men (Labbe et al, ). Apigenin has cytostatic and cytotoxic effects on various cancer cells at different doses (Table ), including pancreatic cancer BxPC‐3, PANC‐1, AsPc‐1, Panc‐1, and MiaPaCa‐2 cells (Johnson & de Mejia, ; Wu et al, ); prostate cancer DU145, LNCaP, and PC‐3 cells (Oishi et al, ; Shukla, Fu, & Gupta, ); breast cancer MDA‐MB‐231, MDA‐MB‐453, MBA‐MB‐468, MCF‐7, MCF‐10A, and SK‐BR‐3 cells (Bai, Jin, Yang, Zhu, & Cai, ; Harrison, Coombs, Delaney, & Hoskin, ; Seo et al, ); ovarian cancer SKOV3 cell (Suh, Jo, Lee, & Lee, ); cervical cancer HeLa, CaSki, and C33A cells (Oh et al, ; Zheng, Chiang, & Lin, ); lung cancer H1299, H460, and H2030 cells (Lee et al, ); glioma and glioblastoma C6, U251, and GL‐15 cells (Santos et al, ; Wang et al, ); osteosarcoma U2OS and MG63 cells (Liu et al, ); papillary thyroid carcinoma BCPAP cell (Zhang et al, ); bladder cancer T‐24 cell (Shi, Shiao, Lee, & Shih, ); colorectal cancer cells (Xu et al, ); and leukemia cells (Ruela‐de‐Sousa et al, ). The antitumor effect of apigenin has also been validated in vivo experiments, indicating that it can significantly prolong the survival time and suppress the tumor growth (Chen, Landis‐Piwowar, Chen, & Dou, ; Shukla et al, ).…”

Section: Antitumor Effectmentioning

confidence: 99%

“…The latter shows that apigenin may be an inhibitor of steroidogenic enzymes and subsequently result in the reduction of androgen production (Wang et al, ), which is beneficial for the treatment of prostate tumor. Conversely, apigenin may also inhibit the tumor cell proliferation, invasion, and metastasis by reducing the Wnt/‐catenin and STAT3 signaling pathways and their downstream target genes VEGF, metalloproteinase‐2/9, and Twist1 (Cao et al, ; Liu et al, ; Santos et al, ; Xu et al, ). Zhu et al () have demonstrated that apigenin can inhibit the epithelial‐mesenchymal transition in prostate cancer, which also contributes to its antimetastatic effect.…”

Section: Antitumor Effectmentioning

confidence: 99%

Apigenin: A current review on its beneficial biological activities

et al. 2017

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Apigenin, identified as 4′,5,7‐trihydroxyflavone, is a natural flavonoid compound present in a variety of fruits, vegetables, functional foods, and medicinal plants. Many studies have revealed that apigenin has the cytostatic and cytotoxic effects on the various cancer cells, prevents the atherogenesis, hypertension, cardiac hypertrophy, ischemia/reperfusion‐induced heart injury, and autoimmune myocarditis, protects the chemicals‐ and ischemia/reperfusion‐induced liver injury, inhibits the asthma, bleomycin‐induced pulmonary fibrosis, abnormal behavior, and oxygen and glucose deprivation/reperfusion‐induced neural cell apoptosis, improves the pancreatitis, type 2 diabetes and its complication, osteoporosis, and collagen‐induced arthritis. These biological effects suggest that apigenin may be a potential health promoting agent. In the article, we will review these effects and possible biochemical mechanisms. Practical applications Apigenin‐rich chamomile, propolis, and garlic oil have been used in the prevention ane cure of hypertension and chemicals‐induced liver injury as food supplements. However, their bioactive components and mechanisms have not been fully elucidated. Apigenin may be a common effective component and play an important role in the process of therapy. In addition, apigenin itself may also be considered as a potential functional food, but the further development will be needed to apply to the prevention and treatment of some‐related diseases in the future.

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“…Chrysin at a concentration range of 5–50 µM has been shown to downregulate the expression of MMP-2 in glioblastoma (50 µM) [139], MMP-9 in gastric cancer (>20 µM) [140] and MMP-10 in MCF-7 breast cancer cell line (>5 µM) [141], thus inhibiting the degradation of ECM and the initiation of the epithelial-mesenchymal transition. On the other hand, Spoerlein et al found that chrysin, and a chrysin-Cu(II) complex, only slightly decreased MMP-2 expression, while having no significant effect on MMP-9 expression in melanoma cells [142].…”

Section: Honey and Cancermentioning

confidence: 99%

Honey and Cancer: Current Status and Future Directions

2016

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Cancer is a leading cause of death worldwide and poses a challenge to treatment. With overwhelming evidence of the role played by diet and lifestyle in cancer risk and prevention, there is a growing interest into the search for chemopreventative or chemotherapeutic agents derived from natural products. Honey is an important source of bioactive compounds derived from plants and recent years have seen an increased interest in its anticancer properties. This review examines the role of honey in targeting key hallmarks of carcinogenesis, including uncontrolled proliferation, apoptosis evasion, angiogenesis, growth factor signalling, invasion, and inflammation. The evidence for honey as an adjunct to conventional cancer therapy is also presented. The review also highlights gaps in the current understanding and concludes that, before translation of evidence from cell culture and animal studies into the clinical setting, further studies are warranted to examine the effects of honey at a molecular level, as well as on cells in the tumour environment.

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Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression

Cited by 74 publications

References 29 publications

Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Apigenin: A current review on its beneficial biological activities

Honey and Cancer: Current Status and Future Directions

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