Flavonol 3-methyl ether glucosides and a tryptophylglycine dipeptide from Artemisia fragrans (Asteraceae)

Delazar, Abbas; Naseri, Maryam; Nazemiyeh, Hossein; Talebpour, Amir-Hossein; Imani, Yousef; Nahar, Lutfun; Sarker, Satyajit D.

doi:10.1016/j.bse.2006.09.006

Cited by 11 publications

(3 citation statements)

References 19 publications

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“…The crude extract of this plant was reported to possess a freeradical-scavenging property (Erdemoglu et al, 2006). As part of our on-going studies on the plants of the Iranian flora (Nazemiyeh et al, 2008(Nazemiyeh et al, , 2007Delazar et al, 2007aDelazar et al, , 2007bDelazar et al, , 2006aDelazar et al, , 2006bDelazar et al, , 2006cDelazar et al, , 2006dDelazar et al, , 2005Delazar et al, , 2004aDelazar et al, , 2004b, we now report on the isolation, structure elucidation and bioactivity of three iridoid glucosides, phloyoside I (1), phlomiol (2) and pulchelloside (3) from the rhizomes of E. laciniata.…”

Section: Introductionmentioning

confidence: 93%

Antibacterial iridoid glucosides from Eremostachys laciniata

Modaressi

Delazar

Nazemiyeh

et al. 2008

Phytotherapy Research

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Eremostachys laciniata (L) Bunge (family: Lamiaceae alt. Labiatae; subfamily: Lamioideae) is one of the 15 endemic Iranian herbs of the genus Eremostachys. A decoction of the roots and flowers of E. laciniata has traditionally been taken orally for the treatment of allergies, headache and liver diseases. Three antibacterial iridoid glucosides, phloyoside I (1), phlomiol (2) and pulchelloside I (3) have been isolated from the rhizomes of this plant. The structures of these compounds were elucidated unequivocally by a series of 1D and 2D NMR analyses. The antibacterial activity and brine shrimp toxicity of these compounds were assessed using the resazurin microtitre assay and the brine shrimp lethality assay, respectively. All three iridoid glycosides 1-3 exhibited from low to moderate levels (MIC = = = = = 0.05-0.50 mg/mL) of antibacterial activity. Of these compounds, compound 3 was the most active, and displayed antibacterial activity against 9 of 12 different strains tested. The most noteworthy activity of 3 was against Bacillus cereus, penicillin-resistant Escherichia coli, Proteus mirabilis and Staphylococcus aureus with an MIC value of 0.05 mg/mL.

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Section: Introductionmentioning

confidence: 93%

Antibacterial iridoid glucosides from Eremostachys laciniata

Modaressi

Delazar

Nazemiyeh

et al. 2008

Phytotherapy Research

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“…Previous phytochemical investigations on A. armeniaca revealed the presence of simple and prenylated coumarins [5] [8] [9], and a-pinene and 1,8-cineole were identified as the major components of the hydro-distilled oils of the aerial parts of this plant [4]. As part of our phytochemical and bioactivity studies on the genus Artemisia [10] [11], we now report on the isolation, identification, and free-radical-scavenging activity of four coumarins (1 -4), of which 1 and 2 are new, three flavonoids, 5 -7, chlorogenic acid (8), tryptophan (9), and a fatty acid (10) from the aerial parts of A. armeniaca.…”

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confidence: 84%

Armenin and Isoarmenin – Two Prenylated Coumarins from the Aerial Parts of Artemisia armeniaca

Mojarrab

Delazar

Moghadam

et al. 2011

Chemistry & Biodiversity

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The reversed-phase (RP) preparative HPLC analyses of the MeOH extract of the aerial parts of Artemisia armeniaca yielded four prenylated coumarins, 7-hydroxy-8-(4-hydroxy-3-methylbutoxy)coumarin (named armenin), 8-hydroxy-7-(4-hydroxy-3-methylbutoxy)coumarin (named isoarmenin), lacarol, and deoxylacarol, together with five other compounds, including three flavonoid glycosides, quercetin 3-O-β-D-glucopyranoside, rutin, and kaempferol 3-O-β-D-glucopyranoside, and chlorogenic acid, and tryptophan. (10E,12Z)-9-Hydroxyoctadeca-10,12-dienoic acid (β-dimorphecolic acid) was isolated from the CH(2)Cl(2) extract. Armenin and isoarmenin were new coumarins. Structures of all compounds were determined by spectroscopic means, including UV, MS, 1D- and 2D-NMR. The in vitro free-radical-scavenging property of the extracts and isolated compounds was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

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“…The essential oils of A. scoparia show strong insecticidal activity against stored-product insects (Negahban et al, 2006), and that of A. spicigera has significant antioxidant property (CanBaser & Buchbauer, 2009). As part of our on-going phytochemical and bioactivity studies on medicinal plants from Iran (Razvi et al, 2008;Modaressi et al, 2009;Nazemiyeh et al, 2009;Asnaashari et al, 2010;Delazar et al, 2006Delazar et al, , 2007Delazar et al, , 2010a, we now report on the antimalarial, free-radical-scavenging and insecticidal activities of different extracts of A. scoparia and A. spicigera.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimalarial, free-radical-scavenging and insecticidal activities of Artemisia scoparia and A. Spicigera, Asteraceae

Afshar¹,

Delazar²,

Janneh³

et al. 2011

Rev. bras. farmacogn.

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Artemisia species (Asteraceae), widespread throughout the world, are a group of important medicinal plants. The extracts of two medicinal plants of this genus, Artemisia scoparia Waldst. & Kit. and A. spicigera C. Koch, were evaluated for potential antimalarial, free-radical-scavenging and insecticidal properties, using the heme biocrystallisation and inhibition assay, the DPPH assay and the contact toxicity bioassay using the pest Tribolium castaneum, respectively. The methanol extracts of both species showed strong free-radical-scavenging activity and the RC50 values were 0.0317 and 0.0458 mg/mL, respectively, for A. scoparia and A. spicigera. The dichloromethane extracts of both species displayed a moderate level of potential antimalarial activity providing IC50 at 0.778 and 0.999 mg/mL for A. scoparia and A. spicigera, respectively. Both species of Artemisia showed insecticidal properties. However, A. spicigera was more effective than A. scoparia.

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Flavonol 3-methyl ether glucosides and a tryptophylglycine dipeptide from Artemisia fragrans (Asteraceae)

Cited by 11 publications

References 19 publications

Antibacterial iridoid glucosides from Eremostachys laciniata

Antibacterial iridoid glucosides from Eremostachys laciniata

Armenin and Isoarmenin – Two Prenylated Coumarins from the Aerial Parts of Artemisia armeniaca

Evaluation of antimalarial, free-radical-scavenging and insecticidal activities of Artemisia scoparia and A. Spicigera, Asteraceae

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