Flavonol Regulation in Tumor Cells

Abstract

Flavonols comprise a group of flavonoid molecules that are widely distributes in fruits and vegetables. There is epidemiological data to suggest that consumption of flavonols can be accompanied by decreased cancer incidence. The anti-oxidant activity of flavonols may have an important role in preventing carcinogenesis. Therapeutic potential of flavonols is indicated by their growth inhibitory action accompanied by a decrease in several hallmarks of cancer such as resistance to apoptosis. Multiple mechanisms of action have been reported for the action of flavonols on cancer cells. Particular emphasis has been directed to inhibitory effects on several protein kinases and on the potential for prooxidant effects. The diversity of actions presents a problem in trying to elucidate primary and secondary effects but it may be a strength of the therapeutic potential of flavonols that it renders development of resistance more difficult for cancer cells. Cancer chemotherapy is usually characterized by the use of drug combinations. Some additive or synergistic combinations have been identified for flavonols and this is an area of ongoing investigation. As with other polyphenolic molecules there have been questions of cellular uptake and bioavailability. Several investigations have been and are being conducted to modify the structures of flavonols with the goal of increasing bioavailability. At present many investigators are sufficiently encouraged by past observations that they are responding to the challenge to optimize the dietary and therapeutic use of flavonols in cancer prevention and treatment.

ALA-Induced Flavonols Accumulation in Guard Cells Is Involved in Scavenging H2O2 and Inhibiting Stomatal Closure in Arabidopsis Cotyledons

“…Besides their roles in plant biology, flavonols have been reported to provide several health benefits to mankind owing to their antioxidant and anti-inflammatory properties (Lee et al, 2015). Moreover, consumption of flavonol-rich food is helpful in lowering the risk of certain diseases (Lea, 2015; Pandey et al, 2015). For example, quercetin and kaempferol have synergistic actions in inhibiting cancer cell proliferation (Arima et al, 2002).…”

Simultaneous Optimal Production of Flavonol Aglycones and Degalloylated Catechins from Green Tea Using a Multi-Function Food-Grade Enzyme

“…Moreover, flavone aglycones exhibited more potent anti-inflammatory effects than their corresponding glycosides [12]. Flavonols, including myricetin, quercetin, and kaempferol, are known to possess numerous beneficial activities, such as antioxidative, anticancer, and antihyperlipidemic effects [13][14][15]. Furthermore, flavonol supplementation was proven to potentially reduce the risk of cardiometabolic disease in a clinical trial [16].…”

Correlation of Antioxidant and Antiproliferative Activity of Amla and Ginger

“…Many chemopreventive therapies utilize polyphenolic components such as curcumin, ginger, Vitamin C, amla, and green tea extracts as cancer therapy [42][43][44][45][46]. The primary mechanism of many chemotherapy and radiotherapy system is generation of reactive oxygen species in the cancer cells to induce apoptosis.…”