Flavonols and flavones of parsley cell suspension culture change the antioxidative capacity of plasma in rats

Hempel, J.; Pforte, H.; Raab, B.; Engst, Wolfram; Böhm, H.; Jacobasch, G

doi:10.1002/(sici)1521-3803(19990601)43:3<201::aid-food201>3.3.co;2-t

Cited by 5 publications

(6 citation statements)

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“…Phenolics in P. crispum can lower H 2 O 2 levels or hydroxyl radicals by increasing the levels of H 2 O 2 ‐detoxifying enzymes in cells, thus preventing DNA damage . Studies have shown that supplementation of diets with fresh P. crispum leaves can increase antioxidant capacity of rat plasma, protect against mitochondrial oxidative damage in the mouse brain and decrease oxidative stress in humans . Our study shows that the P. crispum extract protected 3 T3‐L1 fibroblasts against H 2 O 2 ‐induced DNA damage, suggesting that appropriate addition of the herb in the daily diet might reduce the effects of free radical‐induced carcinogenesis, hence affording some protection against cancer.…”

Section: Resultsmentioning

confidence: 58%

“…Terpenes, phthalides, furanocoumarins, apiin, carotenoids, ascorbic acid and tocopherol are also present in P. crispum . Supplementation of diets with fresh P. crispum leaves increases the antioxidant capacity of plasma in rats and decreases oxidative stress in humans . Zheng et al reported the inhibition of benzo[ a ]pyrene‐induced tumorigenesis in the lungs of mice by myristicin, a major volatile aromatic constituent of parsley leaf oil.…”

Section: Introductionmentioning

confidence: 99%

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Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells

et al. 2015

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BACKGROUND Petroselinum crispum (English parsley) is a common herb of the Apiaceae family that is cultivated throughout the world and is widely used as a seasoning condiment. Studies have shown its potential as a medicinal herb. In this study, P. crispum leaf and stem extracts were evaluated for their antioxidant properties, protection against DNA damage in normal 3T3‐L1 cells, and the inhibition of proliferation and migration of the MCF‐7 cells.RESULTSThe dichloromethane extract of P. crispum exhibited the highest phenolic content (42.31 ± 0.50 mg GAE g−1) and ferric reducing ability (0.360 ± 0.009 mmol g−1) of the various extractions performed. The extract showed DPPH radical scavenging activity with an IC50 value of 3310.0 ± 80.5 µg mL −1. Mouse fibroblasts (3T3‐L1) pre‐treated with 400 µg mL −1 of the extract showed 50.9% protection against H2O2‐induced DNA damage, suggesting its potential in cancer prevention. The extract (300 µg mL −1) inhibited H2O2‐induced MCF‐7 cell migration by 41% ± 4%. As cell migration is necessary for metastasis of cancer cells, inhibition of migration is an indication of protection against metastasis.CONCLUSION Petroselinum crispum has health‐promoting properties with the potential to prevent oxidative stress‐related diseases and can be developed into functional food. © 2015 The Authors. Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells

et al. 2015

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“…We chose to use 4 0 ,5,7-trihydroxyflavone (apigenin, Fig. 3A, inset) a plant polyphenol, flavonoid aglycone derived from green leafy vegetables [29][30][31][32]. Apigenin mediates inhibition of tyrosine kinase activities via interaction with the ATP-binding site of the specific kinase, which results in suppression of oncogene expression [27,[33][34][35][36][37][38][39][40].…”

Section: Jak3 Activity Is Inhibited By Apigeninmentioning

confidence: 99%

IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)

et al. 2010

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a b s t r a c tJanus kinase 3 (JAK3) is a non-receptor tyrosine kinase vital to the regulation of T-cells. We report that JAK3 is a mediator of interleukin-8 (IL-8) stimulation of a different class of hematopoietic relevant cells: human neutrophils. IL-8 induced a time-and concentration-dependent activation of JAK3 activity in neutrophils and differentiated HL-60 leukemic cells. JAK3 was more robustly activated by IL-8 than other kinases: p70S6K, mTOR, MAPK or PKC. JAK3 silencing severely inhibited IL-8-mediated chemotaxis. Thus, IL-8 stimulates chemotaxis through a mechanism mediated by JAK3. Further, JAK3 activity and chemotaxis were inhibited by the flavonoid apigenin (4 0 ,5,7-trihydroxyflavone) at $5 nM IC 50 . These new findings lay the basis for understanding the molecular mechanism of cell migration as it relates to neutrophil-mediated chronic inflammatory processes.

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“…Luteolin (2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-chromenone), myricetin, and quercetin, which are structurally related flavones (Fig. 1a), act as anti-oxidants and free-radical scavengers, dramatically reducing inflammatory responses [24][25][28][29][30][31][32]. Their antioxidant property is related to the number and position of their hydroxyl groups [33].…”

Section: Introductionmentioning

confidence: 99%

A Flavonoid, Luteolin, Cripples HIV-1 by Abrogation of Tat Function

2011

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Despite the effectiveness of combination antiretroviral treatment (cART) against HIV-1, evidence indicates that residual infection persists in different cell types. Intensification of cART does not decrease the residual viral load or immune activation. cART restricts the synthesis of infectious virus but does not curtail HIV-1 transcription and translation from either the integrated or unintegrated viral genomes in infected cells. All treated patients with full viral suppression actually have low-level viremia. More than 60% of treated individuals also develop minor HIV-1 –associated neurocognitive deficits (HAND) due to residual virus and immune activation. Thus, new therapeutic agents are needed to curtail HIV-1 transcription and residual virus. In this study, luteolin, a dietary supplement, profoundly reduced HIV-1 infection in reporter cells and primary lymphocytes. HIV-1inhibition by luteolin was independent of viral entry, as shown by the fact that wild-type and VSV–pseudotyped HIV-1 infections were similarly inhibited. Luteolin was unable to inhibit viral reverse transcription. Luteolin had antiviral activity in a latent HIV-1 reactivation model and effectively ablated both clade-B- and -C -Tat-driven LTR transactivation in reporter assays but had no effect on Tat expression and its sub-cellular localization. We conclude that luteolin confers anti–HIV-1 activity at the Tat functional level. Given its biosafety profile and ability to cross the blood-brain barrier, luteolin may serve as a base flavonoid to develop potent anti–HIV-1 derivatives to complement cART.

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Flavonols and flavones of parsley cell suspension culture change the antioxidative capacity of plasma in rats

Cited by 5 publications

References 0 publications

Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells

Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells

IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)

A Flavonoid, Luteolin, Cripples HIV-1 by Abrogation of Tat Function

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