Flavonols, Flavones, Flavanones, and Human Health: Epidemiological Evidence

Graf, Brigitte A.; Milbury, Paul E.; Blumberg, Jeffrey B.

doi:10.1089/jmf.2005.8.281

Cited by 497 publications

(275 citation statements)

References 47 publications

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“…Therefore, many natural compounds are used to prevent or protect against various degenerative diseases [7]. In this study, we investigated the molecular evidence for protecting against cell degeneration with natural compounds under H 2 O 2 treatment conditions in H9c2 cells.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells

et al. 2007

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Resveratrol, one of polyphenols derived from red wine, has been shown to protect against cell death, possibly through the association with several signaling pathways. Currently numerous studies indicate that cardiovascular diseases are linked to the release of intracellular reactive oxygen species (ROS) often generated in states such as ischemia/reperfusion injury. In the present study, we investigated whether resveratrol has the capability to control intracellular survival signaling cascades involving AMP-activated kinase (AMPK) in the inhibitory process of cardiac injury. We hypothesized that resveratrol may exert a protective effect on damage to heart muscle through modulating of the AMPK signaling pathway. We mimicked ischemic conditions by inducing cell death with H 2 O 2 in H9c2 muscle cells. In this experiment, resveratrol induced strong activation of AMPK and inhibited the occurrence of cell death caused by treatment with H 2 O 2 . Under the same conditions, inhibition of AMPK using dominant negative AMPK constructs dramatically abolished the effect of resveratrol on cell survival in H 2 O 2 -treated cardiac muscle cells. These results indicate that resveratrol-induced cell survival is mediated by AMPK in H9c2 cells and may exert a novel therapeutic effect on oxidative stress induced in cardiac disorders.

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Section: Discussionmentioning

confidence: 99%

Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells

et al. 2007

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“…These protective effects are attributed, in part, to phenolic secondary metabolites [26]- [28]. Initially, the protective effect of dietary phenolics was thought to be due to their antioxidant properties which are the lowering of the levels of free radicals present in the body.…”

Section: Polyphenols In Healthmentioning

confidence: 99%

Phenolics in Human Health

Özcan¹,

Akpinar‐Bayizit²,

Yilmaz‐Ersan³

et al. 2014

IJCEA

200

135

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Abstract-Recent research focuses on health benefits of phytochemicals, especially antioxidant and antimicrobial properties of phenolic compounds, which is known to exert preventive activity against infectious and degenerative diseases, inflammation and allergies via antioxidant, antimicrobial and proteins/enzymes neutralization/modulation mechanisms. Phenolic compounds are reactive metabolites in a wide range of plant-derived foods and mainly divided in four groups: phenolic acids, flavonoids, stilbenes and tannins. They work as terminators of free radicals and chelators of metal ions that are capable of catalyzing lipid oxidation. Therefore, this review examines the functional properties of phenolics.

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“…In the last decade, the beneficial properties of phytochemicals have lead to a vigorous search for novel antioxidants from natural sources, involving the nutritional, pharmacological and medicinal chemistry fields [3][4][5][6][7][8][9][10][11][12][13][14][15][16], with particular emphasis on the prevention of cancer and cardiovascular distress through the consumption of this kind of nutraceuticals in the daily diet [17][18][19][20]. Accordingly, special attention has been paid to phenolic acids, anthocyanins, coumarins, tannins and flavonoids (including flavones and isoflavones), the latter being the largest group among phytochemicals [21].…”

Section: Introductionmentioning

confidence: 99%

A conformational study of hydroxyflavones by vibrational spectroscopy coupled to DFT calculations

Machado

Carvalho

Otero

et al. 2013

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. The conformational preferences of a series of hydroxyflavones were studied by Raman and FTIR spectroscopies, coupled to Density Functional Theory calculations. Special attention was paid to the effect of hydroxyl substitution, due to its importance on the biological activity of these compounds. Their conformational preferences were found to be determined mainly by the orientation of the hydroxylic groups at C 7 and within the catechol moiety, leading to the occurrence of distinct conformers in the solid state. A complete assignment of the experimental spectra was carried out for these molecules, in the light of their most stable conformers and the corresponding predicted vibrational pattern.

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Flavonols, Flavones, Flavanones, and Human Health: Epidemiological Evidence

Cited by 497 publications

References 47 publications

Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells

Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells

Phenolics in Human Health

A conformational study of hydroxyflavones by vibrational spectroscopy coupled to DFT calculations

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