Abstract:We discuss the origin of both non-Abelian discrete family symmetry and Abelian continuous family symmetry, as well as matter parity, from F-theory SUSY GUTs. We propose a minimal model based on the smallest GUT group SU(5), together with the non-Abelian family symmetry D 4 plus an Abelian family symmetry, where fluxes are responsible for doublet-triplet splitting, leading to a realistic low energy spectrum with phenomenologically acceptable quark and lepton masses and mixing. We show how a Z 2 matter parity emerging from F-theory can suppress proton decay while allowing neutronantineutron oscillations, providing a distinctive signature of the set-up.