We investigate the possible size of h → bs in two-Higgs-doublet models with generic Yukawa couplings. Even though the corresponding rates are in general expected to be small due to the indirect constraints from Bs → µ + µ − and Bs-Bs mixing, we find regions in parameter space where h → bs can have a sizable branching ratio well above 10%. This requires a tuning of the neutral scalar masses and their couplings to muons, but then all additional constraints such as B → Xsγ, (g − 2)µ, and h → µ + µ − are satisfied. In this case, h → bs can be a relevant background in h → bb searches and vice versa due to the imperfect b-tagging purity. Furthermore, if h → bs is sizeable, one expects two more scalar resonances in the proximity of m h . We briefly comment on other flavour violating Higgs decays and on the 95 GeV γγ resonance within generic two-Higgs-doublet models.1 Similar analyses were performed in the MSSM [8][9][10], also with additional vector-like fermions [11] and in 2HDMs with of type I and II [12], in aligned 2HDMs [13] as well as in Branco-Grimus-Lavoura [14] 2HDMs [15] and Zee models [16]. The correlations between h → bs and Bs → µ + µ − were considered in Ref. [17].