Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults

Kontogianni, Meropi D.; Vlassopoulos, Antonis; Gatzieva, Alexandra; Farmaki, Aliki‐Eleni; Katsiougiannis, Stergios; Panagiotakos, Demosthenes B.; Kalogeropoulos, Nick; Skopouli, Fotini N.

doi:10.1016/j.metabol.2012.11.007

Cited by 65 publications

(77 citation statements)

References 44 publications

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“…Myhrstad et al (2011) also did not achieve significant results testing meals containing 29 g of coconut oil on postprandial plasma pro-inflammatory cytokines (IL-6 and IL-8) or their gene expression on PBMC, at 3 and 6 h after consumption of the test meals. Moreover, Kontogianni et al (2013) assessed inflammatory markers related to olive oil intake (15 mL) during 6 weeks and found no significant changes in inflammatory markers, including hs-PCR and TNF-α, confirming our results. We know that saturated fats are linked to inflammatory processes [18] .…”

Section: Discussionsupporting

confidence: 87%

Acute Effect of Coconut Oil Consumption Does Not Affect Postprandial Human Cytokines in Healthy Overweight Women

Rocha¹

2016

IJFNS

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The coconut oil is popularly recognized for its anti-inflammatory properties, but research has shown conflicting results. Thus, our aim was to assess the postprandial inflammatory response of moderate coconut oil intake. We evaluated the acute consumption of a breakfast, offered in a single day, containing 25 mL of coconut oil (test) or 25 mL of olive oil (control)on postprandial serum inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-γ and TNF) in healthy overweight women. No change was observed in relation to the effect of fatty meals, the time and the interaction of both factors (meal x time). Thus, despite being a saturated fat source, coconut oil consumption did not promote an inflammatory response. Further studies are needed considering a larger intervention period to check long-term effect.

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Section: Discussionsupporting

confidence: 87%

Acute Effect of Coconut Oil Consumption Does Not Affect Postprandial Human Cytokines in Healthy Overweight Women

Rocha¹

2016

IJFNS

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“…ALA has also demonstrated anti-inflammatory properties in several studies (Guixiang Zhao et al, 2007;G. Zhao et al, 2004), yet not in others (Barceló-Coblijn et al, 2008;Kaul et al, 2008;Kontogianni et al, 2013). This is similar to the effects on triglycerides which have been attenuated (Djoussé et al, 2003;Egert, Kannenberg, Somoza, Erbersdobler, andWahrburg, 2009) or unchanged (Barceló-Coblijn et al, 2008;Harper, Edwards, and Jacobson, 2006;Kaul et al, 2008;Nestel et al, 1997) as well.…”

Section: Fatty Acidsmentioning

confidence: 85%

Stability of bioactives in flaxseed and flaxseed-fortified foods

Edel

Aliani

Pierce

2015

Food Research International

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“…This involves in particular constant background diet and defined low-variable PUFA intake as well as subjects acting as their own controls (cross-over design), and run-in and wash-out phase. Other studies with the aim to modify LA and ALA intake mostly supplemented margarine and/or plant oils additionally to the normal background nutrition of the participants to achieve the desired ratio of LA to ALA. 20,28,29,32,33,[38][39][40][41]43 Studies, where subjects acted as their own controls are rare. 20,39 With the two experimental diets a low-LA (2.78 en%) and a high-ALA (4.98 en%) diet and a high-LA (6.95 en%) and low-ALA (0.27 en%) diet were achieved, which correspond to a LA/ ALA ratio of 0.56 ± 0.27 : 1 and 25.6 ± 2.41 : 1, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…26 In a similar study, a 6-week intervention with ALA from linseed oil (LA/ALA ratio of 1 : 1) resulted in a 47.2% increase of relative EPA amounts in RBCs. 33 The reason for this comparatively small increase after 6 weeks of intervention may be the lower ALA dose of 8.7 ± 2.2 g d −1…”

Section: Rbc Fatty Acid Concentrationsmentioning

confidence: 97%

Effects of a low and a high dietary LA/ALA ratio on long-chain PUFA concentrations in red blood cells

et al. 2018

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aThere is a debate about the optimal dietary ratio of the parent n6 fatty acid linoleic acid (LA) and n3 fatty acid alpha-linolenic acid (ALA) to promote an efficient conversion of ALA to EPA and DHA, which have implications for human health. The aim of the present study was to compare the effects of a low-LA/ high-ALA ( lo LA/ hi ALA) diet with a high-LA/low-ALA ( hi LA/ lo ALA) diet on fatty acid concentrations in red blood cells (RBCs). Fifteen omnivore healthy men (mean age 26.1 ± 4.5 years) with a low initial EPA/DHA status (sum (∑) EPA + DHA% of total fatty acids in RBC at baseline: 4.03 ± 0.17) received both diets for two weeks with a nine-week wash-out phase in between. Fatty acid intake of the subjects was tightly unaffected. The hi LA/ lo ALA diet led to slightly decreased EPA concentrations, while all other fatty acid concentrations remained constant. Compared to our previous study, where we simply increased the ALA intake, our results show that ALA supplementation combined with a reduced LA intake ( lo LA/ hi ALA diet) more efficiently enhanced EPA blood concentrations. The absence of changes in the PUFA pattern in consequence of a LA/ALA ratio of 25.6 ± 2.41 : 1 suggests that the high LA/ALA ratio of the Western diet already leads to a saturation and a further increase of the ratio does not affect the PUFA pattern.

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Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults

Cited by 65 publications

References 44 publications

Acute Effect of Coconut Oil Consumption Does Not Affect Postprandial Human Cytokines in Healthy Overweight Women

Acute Effect of Coconut Oil Consumption Does Not Affect Postprandial Human Cytokines in Healthy Overweight Women

Stability of bioactives in flaxseed and flaxseed-fortified foods

Effects of a low and a high dietary LA/ALA ratio on long-chain PUFA concentrations in red blood cells

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