Fleece bound sealing prevents pleural adhesions

Getman, Vladyslav; Devyatko, Elena; Wolner, Ernst; Aharinejad, Seyedhossein; Mueller, Michael

doi:10.1510/icvts.2005.121129

Cited by 35 publications

(21 citation statements)

References 11 publications

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“…In our study, the animals were reoperated 12 weeks after the initial surgery, corresponding to the period necessary for the hemostatic patch to be completely resorbed, according to the conclusions of Getman et al who also demonstrated a preventive effect of TachoSil® to prevent pleural adhesions in an experimental rat model [31].…”

Section: Discussionmentioning

confidence: 99%

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Nohuz¹,

Darcha

Moreno³

et al. 2009

Gynecol Surg

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The aim of this study was to evaluate the effectiveness of a fibrinogen and thrombin-coated hemostatic sponge (TachoSil®) in the prevention of postsurgical adhesions in a laparoscopic rat model and its histological effects on uterine and peritoneal parenchyma. Design was a prospective randomized blinded study. Setting was in International Laparoscopic Surgery Centre, ClermontFerrand, France. There were 100 sexually mature female Sprague-Dawley rats weighing 240 to 300 g and aged 6-8 weeks. A standardized severe surgical injury induced by scissors and 40-W bipolar coagulation in the rat uterine horn, corpus, and peritoneum was performed to induce adhesion formation. After trauma, group 1 (n=50) received no treatment and group 2 rats (n=50) received TachoSil® applied on injured areas. Twelve weeks after the procedure, repeat laparoscopy was performed and adhesions were scored according to their extent and severity. A hysterectomy and a peritoneal biopsy in the injured area were achieved by laparotomy in order to investigate on a possible earlier effect of TachoSil® on the uterine and peritoneal parenchyma in 49 rats of each group. TachoSil® group adhesion scores showed a significant decrease on the three injured areas: peritoneum (12.96 vs. 21.66), uterine horn (7.22 vs. 15.20), and uterine corpus (5.88 vs. 34.52). TachoSil® group also demonstrated a major decline of uterine fibrosis and inflammation. This study revealed that TachoSil®, an absorbable biomaterial, can reduce postoperative adhesions after laparoscopic surgery on a rat model. TachoSil® also prevents thermo-induced injuries on uterine parenchyma (less fibrosis and less inflammation).

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Section: Discussionmentioning

confidence: 99%

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Nohuz¹,

Darcha

Moreno³

et al. 2009

Gynecol Surg

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“…In thoracic surgery, these adhesions prevent normal re-expansion of the lungs and thus interfere with respiratory function [1], as well as protracting the time until subsequent surgery can be performed, increasing the risk of hemorrhage, restricting the field of view, and damaging pulmonary blood vessels [2–4]. …”

Section: Introductionmentioning

confidence: 99%

Effective new membrane for preventing postthoracotomy pleural adhesion by surface water induction technology

et al. 2017

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BackgroundAfter thoracic surgery, adhesions between the pleura can cause substantial complications. This study investigated the effectiveness of a novel membrane utilizing surface water induction technology to prevent adhesions.MethodsEight beagles were divided into an experimental group (five males) and a control group (three females). The experimental group underwent thoracotomy on both the left and right sides of the chest. Both sides received the membrane, and the membrane on one side was glued to the pleura using tissue adhesive. The control group underwent thoracotomy only on the left side. Two weeks postoperatively, all dogs were sacrificed and adhesions were evaluated macroscopically and microscopically.ResultsSevere adhesion was seen between the parietal and visceral pleura in all control dogs, whereas the experimental group showed minor adhesion in only one dog on one side.ConclusionsOur novel anti-adhesive membrane appeared highly effective in preventing postthoracotomy pleural adhesions.

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“…In addition, for FCGM, clinicians need little preparation because of the commercially-available products. Furthermore, in a study involving a model of pleural defect, the fleece seemed to have had completely dissolved after 12 weeks [11]. …”

Section: Discussionmentioning

confidence: 99%

Fibrinogen-Based Collagen Fleece Graft Myringoplasty for Traumatic Tympanic Membrane Perforation

Choi

Song

2016

J Audiol Otol

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Background and ObjectivesThe aim of this study was to investigate how fibrinogen-based collagen fleece (Tachocomb®) graft myringoplasty (FCGM), performed under microscopic guidance, improves both hearing and tympanic membrane tissue repair in patients with traumatic tympanic membrane perforation (TMP).Subjects and MethodsBetween August 2009 and March 2015, a total of 52 patients with traumatic TMP visited the department of otorhinolaryngology at a secondary medical center. Twenty-nine of these underwent FCGM under microscopic guidance in our outpatient clinic. For each patient, we recorded the location and size of the perforation, the time elapsed from the onset of TMP until the myringoplasty, and the hearing level both before and after myringoplasty.ResultsThe TMP closed completely in all cases (29 of 29 patients). After myringoplasty, the postoperative air-bone gap (ABG) differed significantly from the preoperative ABG. Three of the 29 patients (10.3%) experienced complications. Specifically, 2 presented with otorrhea after FCGM, but conservative management led to improvement without recurrence of perforation. One patient showed delayed facial palsy 1 week after the procedure. The condition of this patient also improved and the palsy was not permanent.ConclusionsFCGM may be an effective treatment option in case of traumatic TMP. The procedure requires no hospitalization, and can be used to avoid traditional tympanoplasty.

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Fleece bound sealing prevents pleural adhesions

Cited by 35 publications

References 11 publications

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Efficiency of TachoSil® to prevent postsurgical adhesion development on laparoscopic rat model

Effective new membrane for preventing postthoracotomy pleural adhesion by surface water induction technology

Fibrinogen-Based Collagen Fleece Graft Myringoplasty for Traumatic Tympanic Membrane Perforation

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