“…Unfortunately, all these operations still may come along with ischemia-related complications, including skin slough, wound dehiscence, and partial-or even full-thickness tissue necrosis [36,37]. However, despite extensive experimental studies [38,39,40], there is still lack of knowledge on the exact mechanism of ischemic tissue damage, especially at the borderline between tissue survival and necrosis, the so-called zone of demarcation.…”