Flexible and bendable acoustofluidics for particle and cell patterning

Acoustofluidic Patterning inside Capillary Tubes Using Standing Surface Acoustic Waves

“…Thus we can conclude that the simulations results have good agreements with the experimental ones. This numerical modelling method was previously shown to be capable of presenting the acoustic pressure field with a reasonable accuracy [49,50,60,75].…”

“…Moreover, previous studies have been focused on rigid SAW devices based on the brittle lithium niobate (LiNbO 3 ) for enriching [44], aligning [36], and patterning [37] microparticles and cells. Whereas so far there are no reports on using flexible thin film SAW devices, which have advantages such as easy integration with microelectronics and other technologies, high power and high speed capabilities [56], and potential applications in flexible microfluidic platforms, body conforming wearable devices, and soft robotics [57][58][59][60].…”

Femtosecond Laser Micromachining of the Mask for Acoustofluidic Device Preparation

“…Efficient actuation of fluids and dexterous handling of micro-objects on the micro-/nanoscale are critical to microfluidic lab-on-a-chip systems. − Applications of surface acoustic waves (SAWs) in microfluidic platforms (often called as acoustofluidics) have recently gained great interest for manipulating fluids, microparticles/cells, in either a digital form (sessile droplet) or a continuous flow (inside a channel/chamber). − These acoustofluidic devices have shown remarkable potential in mixing, , pumping, jetting, , and atomizing , of fluids on the microscale and applications in the fields of biomedicine and chemistry for non-invasive and contactless manipulation, with low cost, good biocompatibility, and conserved cell viability and proliferation capacity. − SAW acoustofluidic devices are generally fabricated by pattering IDTs on a piezoelectric substrate such as a LiNbO 3 or a piezoelectric film on a silicon or Al plate substrate, − which converts the radio frequency (RF) signal into SAWs propagating along the surface of the substrate. When the SAW meets a liquid medium, it changes the wave mode to a leaky SAW and dissipates acoustic energy into liquid through viscous damping, , inducing acoustic streaming in fluids and imparting an acoustic radiation force to the suspended particles/cells in liquids. − …”

“… 1 − 3 Applications of surface acoustic waves (SAWs) in microfluidic platforms (often called as acoustofluidics) have recently gained great interest for manipulating fluids, microparticles/cells, in either a digital form (sessile droplet) or a continuous flow (inside a channel/chamber). 4 − 8 These acoustofluidic devices have shown remarkable potential in mixing, 9 , 10 pumping, 11 jetting, 12 , 13 and atomizing 14 , 15 of fluids on the microscale and applications in the fields of biomedicine and chemistry for non-invasive and contactless manipulation, with low cost, good biocompatibility, and conserved cell viability and proliferation capacity. 16 − 20 SAW acoustofluidic devices are generally fabricated by pattering IDTs on a piezoelectric substrate such as a LiNbO 3 or a piezoelectric film on a silicon or Al plate substrate, 21 − 23 which converts the radio frequency (RF) signal into SAWs propagating along the surface of the substrate.…”

Acoustofluidic Behaviors of Zno/Al Plate/Sheet Acoustic Wave Devices Using Hybrid Modes

“…Applications of surface acoustic waves (SAWs) in microfluidic platforms (often called acoustofluidics) have attracted great interest for actuation and manipulation of fluids, microparticles/cells, in either a digital format (sessile droplet) or continuous flow (fluids inside a microchannel/chamber) [1][2][3]. They have shown superior advantages over other methods, such as simple structure design, small size, low cost, non-invasive and contact-free manner and high precision [4,5].…”