Flexible and Effective Preparation of Magnetic Nanoclusters via One-Step Flow Synthesis

Abstract

Fe3O4 nanoclusters have attractive applications in various areas, due to their outstanding superparamagnetism. In this work, we realized a one-step flow synthesis of Fe3O4 nanoclusters, within minutes, through the sequential and quantitative introduction of reactants and modifier in a microflow system. The enhanced micromixing performance enabled a prompt and uniform supply of the modifier oleic acid (OA) for both nanoparticle modification and nanocluster stabilization to avoid uncontrolled modified nanoparticles aggregation. The size of the nanoclusters could be flexibly tailored in the range of 50–100 nm by adjusting the amount of OA, the pH, and the temperature. This rapid method proved the possibility of large-scale and stable production of magnetic nanoclusters and provided convenience for their applications in broad fields.

High Drug Capacity Doxorubicin-Loaded Iron Oxide Nanocomposites for Cancer Therapy

“…A modern approach uses tannic acid, classical carboxylic acid (polyacrylic, lauric, myristic, or oleic), hyaluronic acid, Tween (polysorbate), polyethylene glycol (PEG), polyethyleneimine, dextran, chitosan, organic polymers, and proteins for colloidal stabilization and optimal magnetic nucleus size formation [4,7,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. For example, PEG-coating enhances the colloidal dispersion and stability of MNPs [4,20,35].…”

Experimental Investigation of Magnetorheological Behavior of Fe3O4@PVP@OA Ferrofluid for Potential Application in Gas Condensate Blockage Reduction

“…67,68 Finally, the last weight loss stage at a rate of 17% between 350 and 600 °C is ascribed to the complete degradation of the coated oleic acid layer on the surface of Fe 3 O 4 @PVP nanoparticles. 67 3.6. TEM.…”

“…Moreover, Fe 3 O 4 @PVP@OA nanoparticles experience two weight loss stages from 120 to 240 °C and from 240 to 350 °C due to the degradation of oleic acid coating the surface physically (5.3%) and chemically (5.7%), respectively. 67,68 Finally, the last weight loss stage at a rate of 17% between 350 and 600 °C is ascribed to the complete degradation of the coated oleic acid layer on the surface of Fe 3 O 4 @PVP nanoparticles. 67 3.6.…”

“…This value is lower than the first weight loss of Fe 3 O 4 @PVP nanoparticles with the hydrophilic properties as the coated oleic acid on the magnetic nanoparticle surface has hydrophobic side chains, minimizing the contact of water molecules with Fe 3 O 4 @PVP nanoparticles. Moreover, Fe 3 O 4 @PVP@OA nanoparticles experience two weight loss stages from 120 to 240 °C and from 240 to 350 °C due to the degradation of oleic acid coating the surface physically (5.3%) and chemically (5.7%), respectively. , Finally, the last weight loss stage at a rate of 17% between 350 and 600 °C is ascribed to the complete degradation of the coated oleic acid layer on the surface of Fe 3 O 4 @PVP nanoparticles …”