Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing

Rajabi, Mina; Roxhed, Niclas; Shafagh, Reza Zandi; Haraldson, Tommy; Fischer, Andreas; Wijngaart, Wouter van der; Stemme, Göran; Niklaus, Frank

doi:10.1371/journal.pone.0166330

Cited by 71 publications

(42 citation statements)

References 36 publications

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“…Rajabi et al . 26 realized and evaluated microneedle patches with two different elasticities of the base substrate but did not analyze surface conditions using SEM.…”

Section: Resultsmentioning

confidence: 99%

Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans

Poveda-Pagán

Hernández-Sánchez

Rhys-Jones-López

et al. 2018

Sci Rep

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The aim of this study was to evaluate the tips and the surface conditions of two types of needles with different quality and their possible alterations after performing different needling on human beings. A total of 160 needles from AguPunt brand were examined. Surface conditions (lumps and scratches) and tip of the needles after needling procedures in humans were tested using a JEOL JSM-6360LV microscopy device. Additionally, a group of physiotherapists assessed the use of both types of needles in clinical practice using a self-reported questionnaire. Both types of needles, after performing different needling on human beings, kept the needle tips well preserved although the dry needle (Type B) suffered very little deformation even touching the bone of the scapula 10 times versus acupuncture needle (Type A), which were deformed slightly. The surface conditions revealed irregularities and scratches in both types of needles but the tips of Type A suffered more damage after different procedures (Odds ratio = 0.04,95% CI:0.01–0.13, p < 0.001). The cellular tissue adhered to the surface was similar in both types of needles and the questionnaire about clinical practice of both types of needles showed that Type B seemed easier than Type A when the physical therapist penetrated the skin and when the needle went out the skin.

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“…Rajabi et al . 26 realized and evaluated microneedle patches with two different elasticities of the base substrate but did not analyze surface conditions using SEM.…”

Section: Resultsmentioning

confidence: 99%

Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans

Poveda-Pagán

Hernández-Sánchez

Rhys-Jones-López

et al. 2018

Sci Rep

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“…E-skin with excellent flexibility and stretchability was designed for personal conditions monitoring with continuously tracking physiological signals, such as, heart rate, breath and skin temperature, which was associated with body motion and driver's status [33,34]. Flexible microneedle patches contacted with the complex topography of skin surface conformally are fabricated for human health and well-being measuring directly on the human body [35]. Soft electronics based on lab-on-skin with similar physical properties of human skin are implemented for continuous hand gesture monitoring and robotic feedback control [36].…”

Section: Introductionmentioning

confidence: 99%

Soft Bimodal Sensor Array Based on Conductive Hydrogel for Driving Status Monitoring

Dong

Yao

Yang

2020

Sensors

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Driving status monitoring is important to safety driving which could be adopted to improve driving behaviors through hand gesture detection by wearable electronics. The soft bimodal sensor array (SBSA) composed of strain sensor array based on ionic conductive hydrogels and capacitive pressure sensor array based on ionic hydrogel electrodes is designed to monitor drivers’ hand gesture. SBSA is fabricated and assembled by the stretchable functional and structural materials through a sol–gel process for guaranteeing the overall softness of SBSA. The piezoresistive strain and capacitive pressure sensing abilities of SBSA are evaluated by the data acquisition system and signal analyzer with the external physical stimuli. The gauge factor (GF) of the strain sensor is 1.638 under stretched format, and –0.726 under compressed format; sensitivity of the pressure sensor is 0.267 kPa−1 below 3.45 and 0.0757 kPa−1 in the range of 3.45–12 kPa, which are sensitive enough to hand gesture detection and driving status monitoring. The simple recognition method for the driver’s status behavior is proposed to identify the driver’s behaviors with the piezoresistive properties of conductive polymers, and the turning angles are computed by the strain and pressure values from SBSA. This work demonstrates an effective approach to integrate SBSA seamlessly into an existing driving environment for driving status monitoring, expanding the applications of SBSA in wearable electronics.

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“…Across multiple physiological time scales associated with wound type and wound healing [ 17 ] the use of MNs has been investigated in the following areas: (a) antimicrobial wound treatment [ 18 , 19 , 20 ]; (b) proliferation of endothelial cells [ 21 , 22 ]; (c) scar repair [ 22 , 23 ]; and, (d) treatment of chronic wounds and burns [ 24 , 25 ]. Related cutting edge applications of MNs include biointerfacing [ 26 ], wound detection [ 27 ], and smart bandages under development combining detection and delivery [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion

et al. 2018

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Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ± 24.5 µm) post-extrusion through a three-dimensional (3D) printed methacrylate-based custom hollow microneedle assembly (circular array of 13 conical frusta) fabricated using stereolithography. With a jetting reliability of 80%, the solvent-sterilized device with a root mean square roughness of 158 nm at the extrusion nozzle tip (d = 325 μm) was operated at a flowrate of 12 mL/min. There was no significant difference between the viability of the sheared and control samples for extrusion times of 2 h (p = 0.14, α = 0.05) and 24 h (p = 0.5, α = 0.05) post-atomization. Factoring the increase in extrusion yield from 21.2% to 56.4% attributed to hydrogel bioerosion quantifiable by a loss in resilience from 5470 (J/m3) to 3250 (J/m3), there was no significant difference in percentage relative payload (p = 0.2628, α = 0.05) when extrusion occurred 24 h (12.2 ± 4.9%) when compared to 2 h (9.9 ± 2.8%) post-atomization. Results from this paper highlight the feasibility of encapsulated cell extrusion, specifically protection from shear, through a hollow microneedle assembly reported for the first time in literature.

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Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing

Cited by 71 publications

References 36 publications

Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans

Scanning electron microscopy examination of needle tips after different procedures of deep dry needling in humans

Soft Bimodal Sensor Array Based on Conductive Hydrogel for Driving Status Monitoring

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion

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