Pressure garment therapy (PGT) and silicone gel sheeting (SGS) predominate non-invasive interventions for burn injuries, but the market lacks a composite solution combining pressure garment fabric (PGF) and medical-grade silicone (e.g. Biopor®AB) for multi-therapeutic efficacy. To address this gap, a versatile composite dressing of PGF-Biopor®AB was developed. PGF-Biopor®AB incorporates dual PGF-SGS therapy, mechanotherapy, and active moisture management, to facilitate recovery of hypertrophic subsidiary structures. The PGF structure enables the application of PGT, while the Biopor®AB silicone characteristics enforce silicone gel therapy (SGT). The PGF-SGS efficacy optimization not only reduces tension but also facilitates water vapor and oxygen penetration, along with hydration of the stratum corneum. Mechanotherapy, involving tension-shielding and pressure redistribution, promotes the reorganization of the collagen-fiber network. For active moisture management, the incorporation of a microchannel structure with active nylon absorbency facilitates effective moisture control through water absorption, retention, and cellular pathways of transport. In this study, the microscale features in the structure were further investigated. Under ISO 10993-5 standard, an over 70% cell viability in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay containing the L929 cell line verified the enhanced cell growth and inhibited proliferation, endorsing the safe usage of PGF-Biopor®AB. Patient studies of one-month efficacy in both high and low-cell-density samples and an early scarless healed wound suggest that over 70% cell viability is sufficient for optimal scar therapeutics. The multifaceted scar repair roles are fulfilled by addressing persistent inflammation, insufficient oxygenation, low levels of perfusion, and scar-healing tension, hence realising the multi-therapeutic efficacy of the composite dressing.