Flexible cotton-AuNP thread electrode for non-enzymatic sensor of uric acid in urine

Abstract

We report on the development of an electrochemical sensor platform based on modi ed cotton bers for the non-enzymatic detection of uric acid (UA), an important biomarker for gout disease. To create the exible electrode, a cotton thread was coated with carbon ink followed by the electrodeposition of AuNPs.Then, differential pulse voltammetry (DPV) was used to evaluate the sensor performances, and a linear detection range between 10 µM and 5.0 mM of uric acid was obtained. The sensor has a low detection limit of 0.12 µM, which is optimal for use in the patients suffering from gout disease which commonly experience concentrations of uric acid in urine higher than 4.46 mM. Furthermore, we found that the detection sensitivity of the platform was not affected by the presence of other physiological compounds present in human urine. The described platform has the potential for integration in a diaper hence enabling rapid detection and screening for gout disease.

3D-Printed Flexible Microfluidic Health Monitor for In Situ Sweat Analysis and Biomarker Detection

“…In Figure 2B, with the increase of glucose concentration from 0.01 to 0. 68 The LOD of glucose, lactate, and uric acid were 0.038, 6.76, and 6.98 μM, respectively. In the Supporting Information, Table S1 shows the comparison of the linear detection range and LOD of the device in this study with other wearable sensors.…”

“…The R -squares of the three fitted curves all exceeded 0.95, indicating a high linear correlation between concentrations of biomarkers and R values. The limit of detection (LOD) was determined by using the following equation: LOD = 3 × S / N , where S represents the standard deviation of the signal derived from a blank solution, and N is the slope of the calibration curve . The LOD of glucose, lactate, and uric acid were 0.038, 6.76, and 6.98 μM, respectively.…”

Biopolymer nanocomposites for food and healthcare applications

“…Cellulose-based nanomaterials have attracted much interest in biomedical application [188,189], for example, using as hydrogels or substrates for electrochemical [190,191] and colorimetric sensors [192][193][194] for increasing sensing sensitivity, water absorbency or mechanical property [195], since it offers abundance of functional group and high specific surface area. Cellulose nanofibrils (CNF) demonstrate notable tendency to form entangling networks facilitating the hydrogel formation [196].…”