In this chapter, the fabrication of microstructure components and devices out of metals and polymers will be described briefly. Influences of the material choice and the basic process parameters with regard to the manufacturing of microstructure components are discussed as are bonding, sealing and packaging of devices. Examples for the choice of material are given. Manufacturing processes for metal microstructure components and microstructures made of certain polymers are described briefly with a clear focus on some special microstructuring methods well established in microstructure technology. Examples of those techniques are given. In the bonding section, the most common bonding and sealing techniques are briefly described. The main focus here is on techniques that allow a prototype manufacturing as well as a small-scale or large-scale series production of devices suitable for reaction or process engineering. Special regard is given to the different methods to obtain devices with mass-flow ranges suitable for industrial production of, e.g., chemicals in microstructure devices. Quality assurance and the long-term stability are also taken into account. Finally, a short view to series production of microstructure components is given. This chapter does not give a complete overview of the large field of generating microstructure devices, but may show some opportunities and, with the references placed at the end of the chapter, some good hints to find more detailed descriptions for the case under consideration.