Flexible (Kapton-based) microsensor arrays of high stability for cardiovascular applications

Lindner, Ernő; Coşofreţ, Vasile V.; Ufer, Stefan; Buck, Richard P.; Kusy, Robert P.; Ash, R. Bruce; Nagle, H. Troy

doi:10.1039/ft9938900361

Cited by 94 publications

(51 citation statements)

References 6 publications

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“…Planar sensors prepared like "coated wire" electrodes (with an ion-selective membrane cast directly over an electronically conducting metal/semiconductor surface, e.g., Pt, Au, a conductive polymer, or the gate area of a field effect transistor [89,90]), without IFS or with extremely small IFS volume, were very sensitive to transmembrane fluxes (e.g., H 2 O, CO 2 , O 2 , etc). They required longer equilibration (conditioning) time [67,88] and were characterized by drifting potentials and modest repeatibility. The majority of the problems experienced with these "all solid-state" microelectrodes were related to the mismatch ("blocked" interfaces) between ion-conducting (IS membrane) and electronically conducting phases (substrate electrode) in which the charge carriers cannot pass from one phase into the other [86].…”

Section: Planar Microfabricated Electrodesmentioning

confidence: 99%

“…Although the incorporation of "liquid reservoirs" into a sensor structure using thin film microfabrication technologies is difficult, planar potassium and hydrogen ISEs fabricated [14,88] with these hydrogel layers provided potential stabilities in the order of 0.1 mV/h and were used successfully for in vivo monitoring of ion concentration changes [91]. Unfortunately, the benefits of these hydrogel film-based sensors quickly faded away with decreasing sensor sizes (hydrogel volumes).…”

Section: Planar Microfabricated Electrodesmentioning

confidence: 99%

“…Due to their low cost and small size, microfabricated ISEs are often aimed for the measurements of a few microliters of samples (e.g., whole blood, serum, plasma, urine, or saliva) in single-use cartridges [13]. They have also been tested for short-term in vivo measurements or closed-loop monitoring of ion activities in biological samples [14,87,88].…”

Section: Planar Microfabricated Electrodesmentioning

confidence: 99%

See 2 more Smart Citations

Performance evaluation criteria for preparation and measurement of macro- and microfabricated ion-selective electrodes (IUPAC Technical Report)

Lindner¹,

Umezawa

2008

Pure and Applied Chemistry

234

168

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Over the last 30 years, IUPAC published several documents with the goal of achieving standardized nomenclature and methodology for potentiometric ion-selective electrodes (ISEs). The ISE vocabulary was formulated, measurement protocols were suggested, and the selectivity coefficients were compiled. However, in light of new discoveries and experimental possibilities in the field of ISEs, some of the IUPAC recommendations have become outdated. The goal of this technical report is to direct attention to ISE practices and the striking need for updated or refined IUPAC recommendations which are consistent with the state of the art of using macro- and microfabricated planar microelectrodes. Some of these ISE practices have never been addressed by IUPAC but have gained importance with the technological and theoretical developments of recent years. In spite of its recognized importance, a generally acceptable revision of the current IUPAC recommendations is far beyond the scope of this work.

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Section: Planar Microfabricated Electrodesmentioning

confidence: 99%

Section: Planar Microfabricated Electrodesmentioning

confidence: 99%

Section: Planar Microfabricated Electrodesmentioning

confidence: 99%

See 1 more Smart Citation

Performance evaluation criteria for preparation and measurement of macro- and microfabricated ion-selective electrodes (IUPAC Technical Report)

Lindner¹,

Umezawa

2008

Pure and Applied Chemistry

234

168

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“…The use of polymeric membrane based pH sensors to replace glass electrode not only benefits modern medicine but it also allows microfabrication of such sensors for implant applications (1) Electrodes based on plasticised PVC membranes coupled with proton-selective ionophores, e.g. tridodecylamine have been reported (2) . However, the use of plasticiser in PVC membrane based electrodes were later found to be the main cause of thrombocity when used as implantable sensors (3,4) .…”

Section: Introductionmentioning

confidence: 99%

A Hydrogen Ion-Selective Sensor Based on Non-Plasticised Methacrylic-acrylic Membranes

Heng

Chern

Ahmad

2002

Sensors

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A methacrylic-acrylic polymer was synthesised for use as a non-plasticised membrane for hydrogen ion-selective sensor incorporating tridodecylamine as an ionophore. The copolymer consisted of methyl methacrylate and n-butyl acrylate monomers in a ratio of 2:8. Characterisation of the copolymer using FTNMR demonstrated that the amount of each monomer incorporated during solution polymerisation was found to be similar to the amount used in the feed before polymerisation. The glass transition temperature of the copolymer determined by differential scanning calorimetry was -30.9 ºC. Potentiometric measurements conducted showed a linear pH response range of 4.3 -9.6 with the response slope of 56.7 mV/decade. The selectivity of the sensors towards hydrogen ions was similar to other plasticiser based membrane electrodes and the logarithmic selectivity coefficients for discrimination against interference cations is close to -9.7. However, the incorporation of a lipophilic anion as membrane additive is essential in ensuring optimum performance of the hydrogen ion sensor.

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“…16,17 Also, the adhesion of such membranes to a solid support is influenced by the water transported through them. 18 A detailed knowledge of the mechanisms involved is, therefore, relevant for developing robust sensors.…”

mentioning

confidence: 99%

Chromoionophore-Mediated Imaging of Water Transport in Ion-Selective Membranes

Zwickl¹,

Schneider²,

Lindner

et al. 1998

ANAL. SCI.

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The K + complex of 2-(4-dipropylaminophenylazo)benzoic acid octadecyl ester (ETH 2418), a new lipophilic chromoionophore, is used to monitor the water uptake of dry solvent polymeric membranes based on 2-nitrophenyl octyl ether/poly(vinyl chloride) (2:1). Upon contact with an alkaline solution, its λmax changes from 535 to 435 nm. This process can be reversed by drying the membranes. From the time-dependent recordings of absorbance changes, an apparent water diffusion coefficient, D * H2O, of 2×10 -8 cm 2 s -1 is determined. In contrast to results obtained with hydrophilic water indicators, no light scattering due to water droplets is observed in the bulk of the membrane.

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Flexible (Kapton-based) microsensor arrays of high stability for cardiovascular applications

Cited by 94 publications

References 6 publications

Performance evaluation criteria for preparation and measurement of macro- and microfabricated ion-selective electrodes (IUPAC Technical Report)

Performance evaluation criteria for preparation and measurement of macro- and microfabricated ion-selective electrodes (IUPAC Technical Report)

A Hydrogen Ion-Selective Sensor Based on Non-Plasticised Methacrylic-acrylic Membranes

Chromoionophore-Mediated Imaging of Water Transport in Ion-Selective Membranes

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