Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint

He, Xuecheng; Fan, Chuan; Luo, Yong; Xu, Tailin; Zhang, Xueji

doi:10.1038/s41528-022-00192-6

Cited by 83 publications

(88 citation statements)

References 53 publications

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“…Obtaining a big enough sample volume is one of the first hurdles to overcome. Additionally, the sweat biosensor’s sensitivity and reliability will be hampered by the evaporation and degradation of sweat chemical information throughout the testing procedure [ 561 ]. As a result, wearable sweat biosensors can detect and analyse biomarkers in sweat in real time with only a tiny quantity of sweat sample, which can address both of the aforementioned technical difficulties simultaneously.…”

Section: Detection Of Analytes From Sweat Using Graphenementioning

confidence: 99%

Graphene and Its Derivatives: Synthesis and Application in the Electrochemical Detection of Analytes in Sweat

et al. 2022

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Wearable sensors and invasive devices have been studied extensively in recent years as the demand for real-time human healthcare applications and seamless human–machine interaction has risen exponentially. An explosion in sensor research throughout the globe has been ignited by the unique features such as thermal, electrical, and mechanical properties of graphene. This includes wearable sensors and implants, which can detect a wide range of data, including body temperature, pulse oxygenation, blood pressure, glucose, and the other analytes present in sweat. Graphene-based sensors for real-time human health monitoring are also being developed. This review is a comprehensive discussion about the properties of graphene, routes to its synthesis, derivatives of graphene, etc. Moreover, the basic features of a biosensor along with the chemistry of sweat are also discussed in detail. The review mainly focusses on the graphene and its derivative-based wearable sensors for the detection of analytes in sweat. Graphene-based sensors for health monitoring will be examined and explained in this study as an overview of the most current innovations in sensor designs, sensing processes, technological advancements, sensor system components, and potential hurdles. The future holds great opportunities for the development of efficient and advanced graphene-based sensors for the detection of analytes in sweat.

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Section: Detection Of Analytes From Sweat Using Graphenementioning

confidence: 99%

Graphene and Its Derivatives: Synthesis and Application in the Electrochemical Detection of Analytes in Sweat

et al. 2022

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“…Furthermore, the proposed microfluidic device’s validation method was tested, including at least off-body test (calibration) and on-body tests to compare both evaluation performances. In addition, a few of them included a simulation to test the mechanical performance [ 14 , 200 ] as well as the performance in terms of fluid flow [ 201 , 202 ]. Mechanical testing is required to establish the level of flexibility and robustness of the microfluidic device in terms of bending, stretching, and twisting to identify which types of extreme activities they are appropriate for use in.…”

Section: Recent Advances Of Ssds: Optimal In Designs Functionalities ...mentioning

confidence: 99%

A Comprehensive Review of the Recent Developments in Wearable Sweat-Sensing Devices

Ibrahim

Sabani

Johari

et al. 2022

Sensors

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Sweat analysis offers non-invasive real-time on-body measurement for wearable sensors. However, there are still gaps in current developed sweat-sensing devices (SSDs) regarding the concerns of mixing fresh and old sweat and real-time measurement, which are the requirements to ensure accurate the measurement of wearable devices. This review paper discusses these limitations by aiding model designs, features, performance, and the device operation for exploring the SSDs used in different sweat collection tools, focusing on continuous and non-continuous flow sweat analysis. In addition, the paper also comprehensively presents various sweat biomarkers that have been explored by earlier works in order to broaden the use of non-invasive sweat samples in healthcare and related applications. This work also discusses the target analyte’s response mechanism for different sweat compositions, categories of sweat collection devices, and recent advances in SSDs regarding optimal design, functionality, and performance.

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“…5,6 The electrochemical method, taking the advantages of simplicity, high sensitivity, and selectivity, as well as rapid response time, has been widely utilized in developing the SWBs. 7,8 Although significant progress has been achieved, there still remain notable challenges. On the one hand, highly sensitive sensing electrodes are desirable for biomarker monitoring due to their low concentration in sweat (e.g., 10−200 μM for glucose, 5−20 mM for lactate, and 2− 200 μM for uric acid (UA)).…”

Section: Introductionmentioning

confidence: 99%

Nonenzymatic Sweat Wearable Uric Acid Sensor Based on N-Doped Reduced Graphene Oxide/Au Dual Aerogels

Chen

et al. 2023

Anal. Chem.

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Sweat wearable sensors enable noninvasive and real-time metabolite monitoring in human health management but lack accuracy and wearable applicability. The rational design of sensing electrode materials will be critical yet challenging. Herein, we report a dual aerogel-based nonenzymatic wearable sensor for the sensitive and selective detection of uric acid (UA) in human sweat. The three-dimensional porous dual-structural aerogels composed of Au nanowires and N-doped graphene nanosheets (noted as N-rGO/Au DAs) provide a large active surface, abundant access to the target, rapid electron transfer pathways, and a high intrinsic activity. Thus, a direct UA electro-oxidation is demonstrated at the N-rGO/Au DAs with a much higher activity than those at the individual gels (i.e., Au and N-rGO). Moreover, the resulting sensing chip displays high performance with a good anti-interfering ability, long-term stability, and excellent flexibility toward the UA detection. With the assistance of a wireless circuit, a wearable sensor is successfully applied in the real-time UA monitoring on human skin. The obtained result is comparable to that evaluated by high-performance liquid chromatography. This dual aerogel-based nonenzymatic biosensing platform not only holds considerable promise for the reliable sweat metabolite monitoring but also opens an avenue for metal-based aerogels as flexible electrodes in wearable sensing.

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Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint

Cited by 83 publications

References 53 publications

Graphene and Its Derivatives: Synthesis and Application in the Electrochemical Detection of Analytes in Sweat

Graphene and Its Derivatives: Synthesis and Application in the Electrochemical Detection of Analytes in Sweat

A Comprehensive Review of the Recent Developments in Wearable Sweat-Sensing Devices

Nonenzymatic Sweat Wearable Uric Acid Sensor Based on N-Doped Reduced Graphene Oxide/Au Dual Aerogels

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