Flexible microneedle array electrode using magnetorheological drawing lithography for bio-signal monitoring

Ren, Lei; Jiang, Qing; Chen, Zhipeng; Chen, Keyun; Xu, Shujia; Gao, Jie; Jiang, Lelun

doi:10.1016/j.sna.2017.10.042

Cited by 71 publications

(58 citation statements)

References 25 publications

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“…These techniques cannot directly fabricate microneedle arrays on a flexible substrate. Wang et al [ 36 , 37 ] fabricated a parylene-based flexible MAE for long-term bio-signal monitoring. However, the fabrication process was extremely complex.…”

Section: Introductionmentioning

confidence: 99%

“…The magneto-rheological drawing lithography (MRDL) technique is a promising fabrication method that meets the above challenges. We have demonstrated that MRDL can easily draw the microneedle array from the droplets of curable magneto-rheological fluid (CMRF) on the flexible substrates under the assistance of an external magnetic field [ 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of Flexible Microneedle Array Electrodes for Wearable Bio-Signal Recording

Ren

Gao

et al. 2018

Sensors

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Laser-direct writing (LDW) and magneto-rheological drawing lithography (MRDL) have been proposed for the fabrication of a flexible microneedle array electrode (MAE) for wearable bio-signal monitoring. Conductive patterns were directly written onto the flexible polyethylene terephthalate (PET) substrate by LDW. The microneedle array was rapidly drawn and formed from the droplets of curable magnetorheological fluid with the assistance of an external magnetic field by MRDL. A flexible MAE can maintain a stable contact interface with curved human skin due to the flexibility of the PET substrate. Compared with Ag/AgCl electrodes and flexible dry electrodes (FDE), the electrode–skin interface impedance of flexible MAE was the minimum even after a 50-cycle bending test. Flexible MAE can record electromyography (EMG), electroencephalography (EEG) and static electrocardiography (ECG) signals with good fidelity. The main features of the dynamic ECG signal recorded by flexible MAE are the most distinguishable with the least moving artifacts. Flexible MAE is an attractive candidate electrode for wearable bio-signal monitoring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication of Flexible Microneedle Array Electrodes for Wearable Bio-Signal Recording

Ren

Gao

et al. 2018

Sensors

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“…For this reason, many studies focus on the coating of MNs with conductive materials represented by Au, Pt, and Ag/AgCl as the WEs, counter electrodes (CEs), and reference electrodes (REs), respectively, in order to enable an MN to function as an electrochemical electrode. In this methodology, metal [ 40 – 46 ], epoxy [ 47 – 49 ], SU-8 [ 50 – 53 ], and polymer [ 53 – 59 ] MNs are coated with metal layers using electroplating or vapor deposition. The covering metal layers are connected to the extract electrodes and the measurement system to conduct the input and output signals.…”

Section: Mns As Sensing Probesmentioning

confidence: 99%

Functionalized microneedles for continuous glucose monitoring

Takeuchi

Kim

2018

Nano Convergence

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Microneedles (MNs) have been established as promising medical devices as they are minimally invasive, cause less pain, and can be utilized for self-administration of drugs by patients. There has been rapid development in MNs for transdermal monitoring and diagnostic systems, following the active research on fabrication methods and applications for drug delivery. In this paper, recent investigations on bio-sensing using MNs are reviewed in terms of the applicability to continuous glucose monitoring system (CGMS), which is one of the main research focuses of medical engineering technologies. The trend of the functionalized MNs can be categorized as follows: (i) as a sensing probe, and (ii) as a biological fluid collector. MNs as in vivo sensors are mainly integrated or coated with conductive materials to have the function as electrodes. MNs as fluid collectors are given a certain geometrical design, such as a hollow and porous structure aided by a capillary action or negative pressure, to extract the interstitial fluids or blood for ex vivo analysis. For realization of CGMS with MNs, a long-term accurate measurement by the MN-based sensing probe or a fluidic connection between the MN-based fluid collector and the existing microfluidic measurement systems should be investigated.

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“…Further, MNE provides a good result for dynamic and long-term bio-potential monitoring compared with the Ag/AgCl electrode. During movement, an arm swing causes a skin shift in the patient, which results in movement artifacts in signal due to the relative position drift between the Ag/AgCl electrode and skin [ 17 , 18 , 19 ]. Additionally, in long-term bio-signal monitoring, the gel used in Ag/AgCl electrode dries after some time, introducing noise in the signal [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Parylene-Coated Microneedle Array Electrode for Wearable ECG Device

Satti

Park

et al. 2020

Sensors

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Microneedle array electrodes (MNE) showed immense potential for the sensitive monitoring of the bioelectric signals by penetrating the stratum corneum with high electrical impedance. In this paper, we introduce a rigid parylene coated microneedle electrode array and portable electrocardiography (ECG) circuit for monitoring of ECG reducing the motion artifacts. The developed MNE showed stability and durability for dynamic and long-term ECG monitoring in comparison to the typical silver-silver chloride (Ag/AgCl) wet electrodes. The microneedles showed no mechanical failure under the compression force up-to 16 N, but successful penetration of skin tissue with a low insertion force of 5 N. The electrical characteristics of the fabricated MNE were characterized by impedance spectroscopy with equivalent circuit model. The designed wearable wireless ECG monitoring device with MNE proved feasibility of the ECG recording which reduces the noise of movement artifacts during dynamic behaviors.

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Flexible microneedle array electrode using magnetorheological drawing lithography for bio-signal monitoring

Cited by 71 publications

References 25 publications

Fabrication of Flexible Microneedle Array Electrodes for Wearable Bio-Signal Recording

Fabrication of Flexible Microneedle Array Electrodes for Wearable Bio-Signal Recording

Functionalized microneedles for continuous glucose monitoring

Fabrication of Parylene-Coated Microneedle Array Electrode for Wearable ECG Device

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