A Polydimethylsiloxane (PDMS) based antenna is designed for skin tumor detection. The antenna functions at 2.45 GHz with a bandwidth of 2.30–2.64 GHz working in the ISM (Industrial, Scientific, and Medical) band. The size of the antenna is 40 × 40 × 1 mm3. This antenna detects tumors in the skin by considering the variations in values of the E-field, J-surf, and H-field. Various analyses such as the distance between the patch and stacked layer skin phantom for different tumor sizes and input power to the antenna are changed and antenna performance is observed. A significant amount of changes is attained which denotes the presence of the tumor. The proposed antenna is fabricated and the corresponding results are analyzed in the Anechoic Chamber. The antenna has an efficiency of 99 % with a Specific Absorption Rate of 1.3846 W/kg which is lower than 1.6 W/kg as per the recommendations of FCC standard.