Flexible polymeric patch based nanotherapeutics against non-cancer therapy

Zhu, Houjuan; Qiang, Justin Mah Jian; Wang, Chen‐Gang; Chan, Chui Yu; Zhu, Qiang; Ye, Enyi; Liu, Yupeng; Loh, Xian Jun

doi:10.1016/j.bioactmat.2022.03.034

Cited by 41 publications

(35 citation statements)

References 187 publications

(237 reference statements)

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“…The application of a functional wound dressing has always been regarded as the critical part of the wound healing process. Due to their robust mechanical properties, high water absorption capacity, three‐dimensional porous structure that mimics the extracellular matrix, as well as the convenience to encapsulate different kinds of therapeutics, hydrogels have been a popular choice for wound dressings in recent years [74–77] . In particular, injectable hydrogel wound dressings with inherent self‐healing capabilities have sparked special research interests, owing to their flexible adaptability in surgical operations to fit irregular wound sites without gel fragmentation.…”

Section: Host‐guest Supramolecular Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

“…to their robust mechanical properties, high water absorption capacity, three-dimensional porous structure that mimics the extracellular matrix, as well as the convenience to encapsulate different kinds of therapeutics, hydrogels have been a popular choice for wound dressings in recent years. [74][75][76][77] In particular, injectable hydrogel wound dressings with inherent self-healing capabilities have sparked special research interests, owing to their flexible adaptability in surgical operations to fit irregular wound sites without gel fragmentation. When applied on skin wounds that are exposed to constant human motions, they may also maintain a greater performance over a longer prolonged life period.…”

Section: Wound Healingmentioning

confidence: 99%

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Recent Advances in Host‐Guest Supramolecular Hydrogels for Biomedical Applications

Wang

Ong

Liu

et al. 2022

Chemistry An Asian Journal

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The recognition-directed host-guest interaction is recognized as a valuable tool for creating supramolecular polymers. Functional hydrogels constructed through the dynamic and reversible host-guest complexation are endowed with a great many appealing features, such as superior self-healing, injectability, flexibility, stimuli-responsiveness and biocompatibility, which are crucial for biological and medicinal applications. With numerous topological structures and host-guest combinations established previously, recent breakthroughs in this area mostly focus on further improvement and fine-tuning of various properties for practical utilizations. The current contribution provides a comprehensive overview of the latest developments in hostguest supramolecular hydrogels, with a particular emphasis on the innovative molecular-level design strategies and hydrogel formation methodologies targeting at a wide range of active biomedical domains, including drug delivery, 3D printing, wound healing, tissue engineering, artificial actuators, biosensors, etc. Furthermore, a brief conclusion and discussion on the steps forward to bring these smart hydrogels to clinical practice is also presented.

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Section: Host‐guest Supramolecular Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Section: Wound Healingmentioning

confidence: 99%

Recent Advances in Host‐Guest Supramolecular Hydrogels for Biomedical Applications

Wang

Ong

Liu

et al. 2022

Chemistry An Asian Journal

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“…Due to the similarity between hydrogels and tissue ECM, they are widely used in the biomedical field as a biocompatible polymeric material ( Caló and Khutoryanskiy, 2015 ). In accordance with many biological materials, hydrogels can be divided into two categories: natural polymers and synthetic polymers ( Ahmed, 2015 ; Zhu et al, 2022 ). So far, many different kinds of hydrogels have been applied in the pharmaceutical industry.…”

Section: Hydrogelsmentioning

confidence: 99%

“…These materials generally have good biocompatibility and biodegradability, combined with practicality and durability. Hydrogels produced through their self-assembly or cross-linking have been widely exploited in drug delivery systems ( He et al, 2018 ; Zhu et al, 2022 ). In addition, smart delivery nanoplatforms constructed with some natural polymers have been used as hydrogel drug depots ( Zhu et al, 2022 ).…”

Section: Hydrogelsmentioning

confidence: 99%

“…Hydrogels produced through their self-assembly or cross-linking have been widely exploited in drug delivery systems ( He et al, 2018 ; Zhu et al, 2022 ). In addition, smart delivery nanoplatforms constructed with some natural polymers have been used as hydrogel drug depots ( Zhu et al, 2022 ). However, these natural polymers have inconsistent hydration and elastic properties.…”

Section: Hydrogelsmentioning

confidence: 99%

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Therapeutic application of hydrogels for bone-related diseases

Liu

Sun

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Bone-related diseases caused by trauma, infection, and aging affect people’s health and quality of life. The prevalence of bone-related diseases has been increasing yearly in recent years. Mild bone diseases can still be treated with conservative drugs and can be cured confidently. However, serious bone injuries caused by large-scale trauma, fractures, bone tumors, and other diseases are challenging to heal on their own. Open surgery must be used for intervention. The treatment method also faces the problems of a long cycle, high cost, and serious side effects. Studies have found that hydrogels have attracted much attention due to their good biocompatibility and biodegradability and show great potential in treating bone-related diseases. This paper mainly introduces the properties and preparation methods of hydrogels, reviews the application of hydrogels in bone-related diseases (including bone defects, bone fracture, cartilage injuries, and osteosarcoma) in recent years. We also put forward suggestions according to the current development status, pointing out a new direction for developing high-performance hydrogels more suitable for bone-related diseases.

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Grid Efferocytosis via Near‐Field Electrostatic Printing Rectifies Skin Immunity

Li,

Wang

et al. 2024

Adv Funct Materials

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Efferocytosis, by phagocytosing and processing apoptotic cells in injured skin, directly influences the immune microenvironment. However, the comprehensive widespread inflammation and disrupted efferocytosis in injured skin cannot be effectively halted. Herein, “Grid Efferocytosis” strategy within injury site is proposed, which segments the inflammation regulatory into grid microdomains, and further rectifies intra‐grid immune microenvironment to accelerate tissue repair. GelMA/PLA/Laponite gridded fiber membranes (GPL) are custom‐designed via near‐field electrostatic printing, and then coated with HAMA‐PBA/EGCG hydrogel by photo‐crosslinking and dynamic borate bonding to form a composite fiber membrane (GPL‐E). Gridded modulation via GPL‐E confines the entire chaotic inflammatory microenvironment into controllable microinflammatory niches. Leveraging the hydrogel coating and boronic ester bond dissociation induced by microenvironmental glucose and reactive oxygen species, GPL‐E achieves dynamic anti‐glucose and anti‐oxidation within microdomains, reconstructing macrophage efferocytosis. Notably, the “grid efferocytosis” recruits repair cells into the grid by magnesium ion release triggered by Laponite exposure on fibers, and enhances endothelial cell vascularization by ≈2.5‐fold. In a mouse diabetic ischemic flap model, implantation of grid GPL‐E maintains flap‐to‐base fusion, attenuates inflammatory infiltration & spread, and improves blood perfusion for flap survival. This study demonstrates that “Grid Efferocytosis” rectifies the immune microenvironment, fostering tissue repair and regeneration.

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Flexible polymeric patch based nanotherapeutics against non-cancer therapy

Cited by 41 publications

References 187 publications

Recent Advances in Host‐Guest Supramolecular Hydrogels for Biomedical Applications

Recent Advances in Host‐Guest Supramolecular Hydrogels for Biomedical Applications

Therapeutic application of hydrogels for bone-related diseases

Grid Efferocytosis via Near‐Field Electrostatic Printing Rectifies Skin Immunity

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