Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors

Lee, Jong-Ha; Cho, Hye Rim; Doo, Gi; Seo, Hyunseon; Lee, Seung–Hyun; Park, Shin Young; Kim, Jin Wook; Qiao, Shutao; Wang, Liu; Kang, Da-Young; Kang, Thomas H.‐K.; Ichikawa, Tomotsugu; Kim, Jong-Hoon; Lee, Hak-Yong; Lee, Woongchan; Kim, Sanghoek; Lee, Sang Kun; Lu, Nanshu; Hyeon, Taeghwan; Choi, Seung Hong; Kim, Dae‐Hyeong

doi:10.1038/s41467-019-13198-y

Cited by 183 publications

(166 citation statements)

References 47 publications

Supporting

Mentioning

165

Contrasting

Order By: Relevance

“…5E). RF power delivered at different frequencies (5,10, and 15 MHz) and different times independently triggers each reservoir. For each case, more than 80% of the insulin releases into the surroundings within 10 to 30 min for gates with sizes of 3 mm by 3 mm, as shown in fig.…”

Section: In Vivo Operation Of a Multiple Release Bioresorbable Drug mentioning

confidence: 99%

“…Specifically, wirelessly delivered electrical current initiated by proximity to a transmission coil leads to electrochemically accelerated dissolution of a metal gate structure that seals drugcontaining reservoirs constructed in a bioresorbable polyanhydride. Unlike hyperthermic actuation (8)(9)(10)(11)(12), this crevice corrosion phenomenon for opening of the gate enables fast and energy-efficient drug release. Exploiting this scheme using metal gates with various shapes and sizes allows the delivery of effective doses to target tissues with desired kinetics.…”

Section: Introductionmentioning

confidence: 99%

“…Recent reports describe active classes of bioresorbable electronic systems that store drugs in porous polymer molecular matrices or chemically conjugated polymer structures, where wirelessly delivered thermal stimuli trigger the release processes ( 8 – 10 ). Tao et al .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion

et al. 2020

View full text Add to dashboard Cite

Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin.

show abstract

Section: In Vivo Operation Of a Multiple Release Bioresorbable Drug mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This kind of devices generally release the therapeutic once the system is triggered by an impulse, like sensing a specific metabolite (Bihar et al, 2018), pressure or strain (Feiner et al, 2019). The main purpose of these multiplex devices is to improve and control in a more efficient way the spatiotemporal release of the drug, so the patient receives the adequate dose (Lee et al, 2019). Regardless of the sub-field of bioelectronics, they all have a common problem: the mechanical, electrical, optical, and chemical sensing modalities have remained isolated from each other in commercial products (Heikenfeld et al, 2018); therefore, it is quite hard to get the whole outlook of the situation employing one single device.…”

Section: Bioelectronicsmentioning

confidence: 99%

Flexible Electronics: Status, Challenges and Opportunities

2020

View full text Add to dashboard Cite

The concept of flexible electronics has been around for several decades. In principle, anything thin or very long can become flexible. While cables and wiring are the prime example for flexibility, it was not until the space race that silicon wafers used for solar cells in satellites were thinned to increase their power per weight ratio, thus allowing a certain degree of warping. This concept permitted the first flexible solar cells in the 1960s (Crabb and Treble, 1967). The development of conductive polymers (Shirakawa et al., 1977), organic semiconductors, and amorphous silicon (Chittick et al., 1969; Okaniwa et al., 1983) in the following decades meant huge strides toward flexibility and processability, and thus these materials became the base for electronic devices in applications that require bending, rolling, folding, and stretching, among other properties that cannot be fulfilled by conventional electronics (Cheng and Wagner, 2009) (Figure 1). Presently there is great interest in new materials and fabrication techniques which allow for highperformance scalable electronic devices to be manufactured directly onto flexible substrates. This interest has also extended to not only flexibility but also properties like stretchability and healability which can be achieved by utilizing elastomeric substrates with strong molecular interactions (Oh et al., 2016; Kang et al., 2018). Likewise, biocompatibility and biodegradability has been achieved through polymers that do not cause adverse effect to the body and can be broken down into smaller constituent pieces after utilization (Bettinger and Bao, 2010; Irimia-Vladu et al., 2010; Liu H. et al., 2019). This new progress is now enabling devices which can conform to complex and dynamic surfaces, such as those found in biological systems and bioinspired soft robotics. These next-generation flexible electronics open up a wide range of exciting new applications such as flexible lighting and display technologies for consumer electronics, architecture, and textiles, wearables with sensors that help monitor our health and habits, implantable electronics for improved medical imaging and diagnostics, as well as extending the functionality of robots and unmanned aircraft through lightweight and conformable energy harvesting devices and sensors. While conventional electronics are very capable of these functions, flexible electronics are intended to expand the mechanical features to adhere to novel form factors through hybrid strategies, or as standalone solutions where the application does not require high computation power, intended to be highly robust to deformation, low cost, thin, or disposable. The definition of flexibility differs from application to application. From bending and rolling for easier handling of large area photovoltaics, to conforming onto irregular shapes, folding, twisting, stretching, and deforming required for devices in electronic skin, all while maintaining device performance and reliability. While early progress and many important innovations have alre...

show abstract

“…Novel NP synthesis methods and device design approaches are thereby required to secure long-term biocompatibility. 70,71 To build an integrated system including standalone type personalized wearable mobile electronics, the NP-based electronic devices should be connected with other device units, including power supply and wireless communication modules, 72,73 which often requires modification of material compositions and device designs of the NP-based electronics. Despite these remaining issues, the potential of the NP-based soft bioelectronics is so great that overarching clinical challenges are expected to be solved while many novel industrial opportunities are to be created.…”

Section: Wearable and Implantable Electronicsmentioning

confidence: 99%