Flexible Transient Bioelectronic System Enables Multifunctional Active‐Controlled Drug Delivery

Abstract

On-demand drug delivery systems (DDSs) have tremendous promise for clinical in vivo personalized drug delivery. However, the current DDSs are monofunctional and unable to meet the individualized needs of patients. Herein, a biodegradable multifunctional active-controlled drug delivery system (ADDS) is reported. The device can be implanted in various tissues with valves controlled by the deactivation of magnesium (Mg) for rapid drug release from drug reservoirs and long-term drug delivery with the biodegradation of the ADDS. Multiple chambers are constructed by designing a structure with tandem Mg valves and aligning them in the z-axis direction, allowing the system to deliver drugs in a pulsatile or sequential manner. The biodegradability of the entire system minimizes the potential side effects of the ADDS. The application of the device for drug delivery in rats confirmed its ability to perform pulsatile delivery in vivo. The excellent biocompatibility and dual timeline drug delivery capability of this system are demonstrated with cellular and in vitro vascular bioreactors. This multifunctional ADDS will play an important role in precise drug delivery in the treatment of chronic diseases and diseases with complications.

On-demand drug delivery bioelectronics through a water-processable low dimensional highly conductive MXene layer

“…The materials used in various previously reported gate valve-type drug delivery bioelectronics were general metal materials (Mg, Mo, etc.). 12,13 Compared to existing materials that have been manufactured through a vacuum process, MXene materials can be easily manufactured through a solution process and have the advantage of minimizing drug loss due to the vacuum process. MXene also features quite excellent conductivity like metallic materials, but it was necessary to check whether degradation due to oxidation and reduction occurs under electrochemical conditions like metallic materials in this system.…”

“…Biocompatible metallic materials that undergo crevice reactions in biofluids upon a voltage trigger can serve as actively controlled gates for electrically controlled drug-delivery systems, enabling customizable, programmable control over the timing of release events. 12,13 MXene is a term for layered transition metal compounds of intrinsic metallicity. 14 MXenes constitute a large family of compounds and can be represented as M n +1 X n T x ( n = 1–3), where “M” is an early transition metal, “X” is carbon or nitrogen, and “T” stands for the hydrophilic surface terminations (–O–, –F, and –OH).…”

A soft implantable energy supply system that integrates wireless charging and biodegradable Zn-ion hybrid supercapacitors

“…To date, most drug delivery devices are nonbiodegradable and designed with a destructive drug release mechanism, which makes them incapable of releasing drugs multiple times or maintaining controlled dosage over time, while necessitating secondary surgery for device extraction after implantable uses ( 73 , 74 ). Recently, some novel electrically controlled DDSs made of biodegradable materials have been developed ( 75 , 76 ), addressing drug leakage concerns during implantation and enabling pulsed drug release. Despite this, achieving precise drug release control (including time and rate) remains a great challenge.…”

Degradable Antimicrobial Ureteral Stent Construction with Silver@graphdiyne Nanocomposite

“…Thus, a suitably designed artificial simulated device can produce an effect comparable to animal experiments while avoiding harm to animals. [ 44 ] The stent test setup is depicted in Figure S5 (Supporting Information) and was tested under axial tension and radial compression ( Figure a). The radial pressure test results (Figure 5b,c) showed that the pressures required to compress 50% of the stent diameter were 3.31±0.09 N (W0), 41.61±4.48 N (W1), 64.78±5.23 N (W2), 74.91±2.21 N (W4) and 27.48±5.98 N (W8).…”