Flibanserin Approval: Facts or Feelings?

Simon, James A.; Goldstein, Irwin; Kim, Noel N.; Freedman, Murray A.; Parish, Sharon J.

doi:10.1016/j.esxm.2016.03.025

Cited by 8 publications

(8 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 -19 While the increase in sexually satisfying events was modest (about 1 extra event per month), some have suggested that the frequency of sexual activity may not be the best measure of sexual function in women. 61 Further, responders to this drug showed a return to near-normal premenopausal frequencies of sexual activity in a separate analysis. 61 The drug is generally well tolerated, with common adverse effects being somnolence, dizziness, and fatigue.…”

Section: Flibanserinmentioning

confidence: 93%

“…61 Further, responders to this drug showed a return to near-normal premenopausal frequencies of sexual activity in a separate analysis. 61 The drug is generally well tolerated, with common adverse effects being somnolence, dizziness, and fatigue. 18,19 Flibanserin has been associated with orthostatic hypotension with alcohol use and carries a boxed warning highlighting this potential interaction.…”

Section: Flibanserinmentioning

confidence: 93%

See 1 more Smart Citation

Sexual dysfunction in women: Can we talk about it?

Faubion

Parish²

2017

CCJM

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Flibanserinmentioning

confidence: 93%

Section: Flibanserinmentioning

confidence: 93%

Sexual dysfunction in women: Can we talk about it?

Faubion

Parish²

2017

CCJM

Self Cite

View full text Add to dashboard Cite

show abstract

“…Among the OTUs with consistently positive relationships with other OTUs (e.g. OTUs 7,9,10,[12][13][14][15][16][17]20), most were Firmicutes, with OTU7 (Corynebacterium) an Actinobacteria and OTU20 (Akkermansia) a Verrucomicrobia, that had low overall sequence counts that often tracked each other. Ultimately, no clear trend was identified suggesting that more similar OTU or more different OTU have any predetermination for positive or negative correlations (S1 Table).…”

Section: Plos Onementioning

confidence: 99%

“…While Sildenafil has shown improvements in clitoral blood flow and sexual arousal in postmenopausal women [13], its clinical efficacy and high risk of adverse effects such as headaches, flushing, rhinitis, and nausea have led to concern for its true clinical benefit in women [14], [15]. Flibanserin can improve sexual desire in postmenopausal women [16], however its efficacy in improving the physiological problems associated with FSD have not been demonstrated [17], [18].…”

Section: Introductionmentioning

confidence: 99%

The rodent vaginal microbiome across the estrous cycle and the effect of genital nerve electrical stimulation

et al. 2020

View full text Add to dashboard Cite

Treatment options are limited for the approximately 40% of postmenopausal women worldwide who suffer from female sexual dysfunction (FSD). Neural stimulation has shown potential as a treatment for genital arousal FSD, however the mechanisms for its improvement are unknown. One potential cause of some cases of genital arousal FSD are changes to the composition of the vaginal microbiota, which is associated with vulvovaginal atrophy. The primary hypothesis of this study was that neural stimulation may induce healthy changes in the vaginal microbiome, thereby improving genital arousal FSD symptoms. In this study we used healthy rats, which are a common animal model for sexual function, however the rat vaginal microbiome is understudied. Thus this study also sought to examine the composition of the rat vaginal microbiota. Treatment rats (n = 5) received 30 minutes of cutaneous electrical stimulation targeting the genital branch of the pudendal nerve, and Control animals (n = 4) had 30-minute sessions without stimulation. Vaginal lavage samples were taken during a 14day baseline period including multiple estrous periods and after twice-weekly 30-minute sessions across a six-week trial period. Analysis of 16S rRNA gene sequences was used to characterize the rat vaginal microbiota in baseline samples and determine the effect of stimulation. We found that the rat vaginal microbiota is dominated by Proteobacteria, Firmicutes, and Actinobacteria, which changed in relative abundance during the estrous cycle and in relationship to each other. While the overall stimulation effects were unclear in these healthy rats, some Treatment animals had less alteration in microbiota composition between sequential samples than Control animals, suggesting that stimulation may help stabilize the vaginal microbiome. Future studies may consider additional physiological parameters, in addition to the microbiome composition, to further examine vaginal health and the effects of stimulation.

show abstract

“…While Sildenafil has shown improvements in clitoral blood flow and sexual arousal in postmenopausal women (13), its clinical efficacy and high risk of adverse effects such as headaches, flushing, rhinitis, and nausea have led to concern for its true clinical benefit in women (14,15). Flibanserin can improve sexual desire in postmenopausal women (16), however its efficacy in improving the physiological problems associated with FSD have not been demonstrated (17,18).…”

Section: Introductionmentioning

confidence: 99%

The rodent vaginal microbiome across the estrous cycle and the effect of genital nerve electrical stimulation

Levy

Bassis

Kennedy

et al. 2019

Preprint

View full text Add to dashboard Cite

Treatment options are limited for the approximately 40% of postmenopausal women worldwide who suffer from female sexual dysfunction (FSD). Neural stimulation has shown potential as a treatment for genital arousal FSD, however the mechanisms for its improvement are unknown. One potential cause of some cases of genital arousal FSD are changes to the composition of the vaginal microbiome, which is associated with vulvovaginal atrophy. The primary hypothesis of this study was that neural stimulation may induce healthy changes in the vaginal microbiome, thereby improving genital arousal FSD symptoms. This study also sought to examine the composition of the rat vaginal microbiome, which is understudied. Nulliparous female rats were used. Treatment animals (n=5) received 30 minutes of cutaneous electrical stimulation targeting the genital branch of the pudendal nerve, and Control animals (n=4) had 30-minute sessions without stimulation. Vaginal lavage samples were taken during a 14-day baseline period including multiple estrous periods and after twice-weekly 30-minute sessions across a six-week trial period. Samples were sequenced at the University of Michigan Host Microbiome Initiative and analyzed for baseline bacterial trends and for changes due to stimulation. We found that the rat vaginal microbiome is dominated by Proteobacteria, Firmicutes, and Actinobacteria phyla bacteria, which changed in abundance during the estrous cycle and in relationship to each other. While the overall stimulation effects were unclear, some Treatment animals had lower variance in the microbiome diversity for sequential samples than Control animals, suggesting that stimulation may help normalize the vaginal microbiome. Future studies may consider additional physiological parameters, in addition to the microbiome composition, to further examine vaginal health and the effects of stimulation.

show abstract

Flibanserin Approval: Facts or Feelings?

Cited by 8 publications

References 4 publications

Sexual dysfunction in women: Can we talk about it?

Sexual dysfunction in women: Can we talk about it?

The rodent vaginal microbiome across the estrous cycle and the effect of genital nerve electrical stimulation

The rodent vaginal microbiome across the estrous cycle and the effect of genital nerve electrical stimulation

Contact Info

Product

Resources

About