In Grand Unified Theories (GUTs) from orbifold and various string constructions the generic vector-like particles do not need to form complete SU (5) or SO(10) representations. To realize them concretely, we present orbifold SU (5) models, orbifold SO(10) models where the gauge symmetry can be broken down to flippedsymmetries, and F-theory SU (5) models. Interestingly, these vector-like particles can be at the TeV-scale so that the lightest CP-even Higgs boson mass can be lifted, or play the messenger fields in the Gauge Mediated Supersymmetry Breaking (GMSB). Considering GMSB, ultraviolet insensitive Anomaly Mediated Supersymmetry Breaking (AMSB), and the deflected AMSB, we study the general gaugino mass relations and their indices, which are valid from the GUT scale to the electroweak scale at one loop, in the SU (5) models, the flipped SU (5) × U (1) X models, and the Pati-Salam SU (4) C × SU (2) L × SU (2) R models. In the deflected AMSB, we also define the new indices for the gaugino mass relations, and calculate them as well. Using these gaugino mass relations and their indices, we may probe the messenger fields at intermediate scale in the GMSB and deflected AMSB, determine the supersymmetry breaking mediation mechanisms, and distinguish the four-dimensional GUTs, orbifold GUTs, and F-theory GUTs.