BACKGROUNDThe COVID-19 pandemic of 2020-2021 presented numerous challenges to higher education in North America and around the world, causing universities and colleges to change the way courses were delivered practically overnight. Most North American universities offering agriculture and natural resources curricula were able to meet this challenge, as did many K-12 schools. Even institutions that had very small or non-existent hybrid or on-line course offerings rapidly evolved to meet this challenge and need. The purpose of this paper, and the Natural Sciences Education (NSE) journal special section, "Natural Science Education in a COVID-19 World", is to highlight many of the ways course instructors, along with K-12 and postsecondary institutions, met this challenge. This special section of NSE consists of 23 papers developed to demonstrate the abilities of 20 universities and two secondary settings in North America to meet the challenges in teaching and learning regarding agriculture and natural sciences during this difficult time period (Figures 1 and 2).