Andragogy, the art and science of helping adults learn, is a learner-centric conceptual framework that considers adult learner characteristics and their motivations for learning. These motivations range from internal will, readiness to learn, and relevance to one's own life. The flipped classroom, an increasingly popular educational method for both learners and educators, aligns with an andragogical approach as it uses classroom time for application of knowledge and critical thinking rather than for a passive didactic lecture. The growing body of educational research demonstrating increased performance and knowledge retention using this method has led to its incorporation into graduate medical education materials, including the National Neonatology Curriculum. In this article, the authors review how the flipped classroom, an active educational method that embraces the tenets of adult learning theory, may be more effective in graduate medical education compared with traditional lecture. Objectives After completing this article, readers should be able to: 1. Recognize the different learning needs and preferences of adult learners. 2. Explain the benefits of active educational methods, such as the flipped classroom, for adult learners. 3. Describe the educational research supporting the development of the National Neonatology Curriculum. AN INTRODUCTION TO ADULT LEARNING THEORY Pedagogy, the art and science of teaching children, is a teacher-centric educational approach in which the teacher has full responsibility for decision-making and the learning environment. Pedagogical approaches to education are the predominant form of instruction in higher education in the United States for both children and AUTHOR DISCLOSURE Drs French, Arias-Shah, Gisondo, and Gray have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.