Floating Drug Delivery System: A Review

Sharma, Vijay; Rathore, Devender Singh; Kumar, Amit

doi:10.32553/ijmbs.v4i8.1333

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…of Alginate-HPMC K4M Microbeads 17,18 : The microbeads of drugs were prepared using the Ionotropic gelation technique. This method accurately weighed the quantity of drugs properly dispersed into 50 ml sodium alginate solution (1.50 % w/v) and thoroughly mixed at 200-600 rpm, using a mechanical stirrer.…”

Section: Preparationmentioning

confidence: 99%

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2022

IJPSR

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The objective of the present investigation was to develop an alginate-HPMC K4M microbead-based gastro-retentive drug delivery system incorporating Famotidine for the treatment of gastrointestinal ulcers. The 3 2 full factorial designs were used for the optimization of famotidine-loaded floating microbeads. Two factors were evaluated, each at 3 levels; experimental trials were performed for all nine possible combinations. The amount of HPMC K4M (X1) and rotations of stirring speed (X2) were selected as independent variables. The % entrapment efficiency, % drug release at 12 hr, and % buoyancy were selected as dependent variables. The morphological properties, mean particle size, drug entrapment efficiency, drug loading, in-vitro buoyancy studies, in-vitro drug release, and in-vivo antiulcer activity of microbeads were all investigated. The effect of formulation variables on the response variables was statically evaluated by applying ANOVA at a 0.05 level using the software Design Expert® 13 (Stat-Ease, USA). The average size of optimized alginate-HPMC K4M microbeads was 0.86±0.35mm, with estimated entrapment effectiveness of 71.43± 0.21%, cumulative drug release of 98.75± 0.50% and percent buoyancy of 88.82±0.26%. Alginate -HPMCK4M microbeads containing Famotidine were successfully prepared using full 3 2 factorial designs and can be utilized to treat peptic ulcers efficiently. In-vivo, antiulcer activity indicated that the improved microbeads formulation might prevent ulcer formation in rats' stomachs. The method presented appears to be promising for drug delivery to the stomach.

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Section: Preparationmentioning

confidence: 99%

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2022

IJPSR

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“…One of the approaches for achieving a prolonged and predictable drug delivery profile in GIT is to control the gastric retention time of the formulation. And this can be achieved by developing a Gastro retentive drug delivery system (GRDDS) which prolongs the residence time of the drug in the upper part of the gastrointestinal tract 2,3,4 .…”

Section: Introductionmentioning

confidence: 99%

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2023

IJPSR

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The absorption of drugs through the gastrointestinal tract is a highly variable process; prolonging gastric retention of the dosage form extends the time for drug absorption. A novel drug delivery system overcomes the physiological problems of short gastric retention by decreasing fluctuations in blood drug concentration with subsequent reduction in undesirable toxicity and poor efficiency. Various approaches have been introduced to prolong gastric residence time, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bio-adhesive systems, high density systems, modified shape systems, etc. Bilayer floating drug delivery systems are the most promising drug delivery system, which exhibits a unique combination of floatation and bilayer, leading to prolongation in residence time in the stomach. Floatation is achieved due to bulk density being less than gastric fluids. So, the system remains buoyant in the stomach for a prolonged period, releasing the drug slowly at the desired rate and thus increasing the bioavailability of narrow absorption window drugs. This review entitles the floating drug delivery system principle and current technology used in the development. Also, it sheds light on the advantages and Total 6 disadvantages to be there disadvantages, the need for floating bilayer tablets, challenges in bi-layer tablet manufacturing, and characterization and evaluation methods for bilayer floating tablets.

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“…Floating drug delivery systems are designed to deliver drugs with low intestinal solubility or poor stability into the stomach by floating over the gastric fluid due to their low-density [ 1 , 2 ]. These dosage forms are embedded within tablets made of hydroxypropyl cellulose and sodium and citric bicarbonate, two gas-generating agents that, when coming into contact with gastric fluid, generate carbon dioxide, which promotes the floating of the tablets [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Controlled-Release Floating Bilayer Tablets of Esomeprazole and Clarithromycin

et al. 2022

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Controlled-release effervescent floating bilayer tablets reduce dosage frequency and improve patient compliance with enhanced therapeutic outcomes. Generally, two different tablets of clarithromycin and esomeprazole, respectively, are given for the treatment of Helicobacter pylori infection and it might be worth incorporating both in a single tablet. In the current study, controlled-release floating bilayer tablets of clarithromycin and esomeprazole (F1–F4) were developed with different rates of polymeric materials by a direct compression method. During the formulation, Fourier-transform infrared spectroscopy (FTIR) analysis was performed for possible interactions between drugs and excipients. No interactions between drugs and excipients were noted. Moreover, the bilayer tablets’ thickness, diameter, friability, hardness, weight variation, dissolution, and percent purity were found within the acceptable limits. The floating lag time and total floating time of all formulations were found to be < 25 s and 24 h, respectively. The release of both the clarithromycin and esomeprazole started at the same time from the controlled-release floating bilayer tablets by anomalous non-Fickian diffusion, and the polymeric materials extended the drug release rate up to 24 h. In the case of F1, the results approached ideal zero-order kinetics. The dissolution profiles of the tested and reference tablet formulations were compared, but no significant differences were observed. It can be concluded that such controlled-release effervescent floating bilayer tablets can be efficiently used in clinical practice to reduce dosage frequency and increase patient compliance with continuous drug release for 24 h, which ultimately might enhance therapeutic efficacy.

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Floating Drug Delivery System: A Review

Cited by 3 publications

References 8 publications

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Preparation and Characterization of Controlled-Release Floating Bilayer Tablets of Esomeprazole and Clarithromycin

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