Floating drug delivery system: an outlook

Choudhury, Ananta; Renthlei, Lalmalsawmi; Dewan, Manjima; Ahmed, Raju; Barakoti, Himal; Dey, Biplab Kumar

doi:10.18231/j.joapr.2019.003

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Each run used a minimum of three tablets to evaluate, then averaged. The data is expressed in kg/cm2 unit [14]. For the friability data, a total of 20 tablets were dust-free, then weighed.…”

Section: Evaluation Of Physical Characteristics Of the Tabletsmentioning

confidence: 99%

The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet

Nur Hidayah,

Ardiana Wati,

Yuniarti

et al. 2023

J. Food Pharm. Sci

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Creatine monohydrate has been developed as a neuroprotective agent and can penetrate in vitro model of the blood-brain barrier. However, its delivery is hampered by its limited capacity of creatine transporter. The floating system is known to increase the residence time of drugs in the stomach; thus, the active substances can be absorbed more optimally. Therefore, this study is aimed to develop creatine monohydrate floating tablets by optimizing the proportion of HPMC K100M and NaHCO2 and evaluating the quality of floating tablets. The formula was designed Simplex Lattice Design method. Tablets were prepared by the wet granulation method and evaluated for granule and tablet parameters. The results showed that HPMC K100M significantly increased flow time, absorption rate, hardness, floating time, swelling index; decreased index tap, fragility, and floating lag time. Meanwhile, an increase in NaHCO2 significantly affects an increase in floating lag time. The optimum formula obtained was 18.87% HPMC K100M and 21.12% NaHCO2. Verification of the optimum formula showed that tablet parameters were not significantly different from the predicted formula. The studies suggest that this prototype can be developed to increase creatine residence time in the stomach.

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Section: Evaluation Of Physical Characteristics Of the Tabletsmentioning

confidence: 99%

The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet

Nur Hidayah,

Ardiana Wati,

Yuniarti

et al. 2023

J. Food Pharm. Sci

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“… Local availability (especially in developing nations): Because of broad range of uses for gum and mucilage in many sectors, the government of India and other similar developing nations actively promotes the cultivation of plants as pharmaceutical excipients.  Patient acceptability as well as public acceptance: Natural materials be at a lower risk of side effects and adverse outcomes than synthetic ones (14).…”

Section: Classification Of Polymers Used In Mouth Dissolving Filmmentioning

confidence: 99%

Polymers used in mouth dissolving film: A review

Maske¹,

Mahajan²,

Bhalerao³

2022

World J. Adv. Res. Rev.

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The oral route is one of the most important routes for local and systemic drug delivery, as it has a large surface, high permeability, and rich blood supply. Mouth dissolving films, are now becoming more popular than fast-dissolving tablets. The films are designed to disintegrate quickly when they come into touch with a surface that contains water, such the tongue. This allows the consumer to consume the product without the use of water. It can boost patient compliance and provide you a marketing advantage. The polymer used in mouth dissolving films is crucial to their quick dissolution and disintegration. The polymer must be non-toxic, non-irritating, flavorless, and simple to use. Natural and synthetic polymers are the two types of polymers that are employed. Natural polymers used in formulation of film include chitosan, gaur gum, xanthan gum, soy polysaccharide, gellan gum, locust bean gum, maltodextrin, and rosin. Hydroxypropyl cellulose, polyvinyl pyrrolidone, Hydroxypropyl Methylcellulose, Polyethylene Oxide, and Polyvinyl Alcohol are synthetic polymers that are frequently used to make films. The current overview gives a description of the numerous polymers that are utilized to make films that dissolve in the mouth.

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“…Mekanisme kerja dari metode ini, dimana terdapat agen effervescent yang berperan dalam menghasilkan gas karbondioksida ketika berinteraksi dengan cairan di dalam lambung. Gas karbondioksida tersebut akan terjebak di dalam polimer yang mengembang membentuk lapisan gel di sekeliling tablet, sehingga membuat tablet dapat mengapung dengan cepat di dalam cairan lambung (10) (11).…”

Section: Hasil Penelitian Dan Pembahasan Pengembangan Sediaan Floatin...unclassified

Kajian Pengembangan Sediaan Floating Sustained Release Tablet

Aulia

Priani

Aryani

2022

BCSP

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Abstract. Floating sustained release tablets were developed to increase the elimination half-life and bioavailability of the drug because it is able to release the active substance for a long duration by a floating mechanism in gastric fluid. This study aims to examine the development of floating tablets for the purpose of sustained release in terms of formulation and manufacturing methods, as well as the effect of developing floating sustained release tablets on pharmacokinetic parameters. The research method used is a systematic literature review by searching for international articles from reputable publishers. The results showed that floating sustained release tablet preparations had been developed for active substances such as alfuzosin HCl, baclofen, cephalexin, famotidine, imanitib mesylate, meberevine HCl, metformin HCl, and troxipide which had met the requirements of a good preparation, namely having a floating lag time in the range 5-600 seconds and a floating duration time of more than 12 hours. The most widely used manufacturing method is the effervescent with the addition of polymer and the presence of an effervescent , namely the reaction between sodium bicarbonate and organic acids (citric acid or tartaric acid). Floating sustained release tablets were able to increase the value of pharmacokinetic parameters such as t1/2, tmax and increase AUC in the range of 2.74-133.8%. Abstrak. Sediaan floating sustained release tablet dikembangkan untuk meningkatkan waktu paruh eliminasi dan ketersediaan hayati obat karena mampu melepaskan zat aktif dalam durasi yang panjang dengan mekanisme mengapung di dalam cairan lambung. Penelitian ini bertujuan untuk mengkaji pengembangan sediaan floating tablet untuk tujuan sustained release dalam hal formulasi dan metode pembuatan, serta pengaruh pengembangan sediaan floating sustained release tablet terhadap parameter farmakokinetik. Metode penelitian yang digunakan yaitu systematic literatur review dengan cara mencari artikel internasional dari penerbit bereputasi. Hasil penelitian ini menunjukan bahwa sediaan floating sustained release tablet sudah dikembangkan untuk zat aktif seperti alfuzosin HCl, baclofen, cephalexin, famotidine, imanitib mesylate, meberevine HCl, metformin HCl, dan troxipide yang dimana telah memuhi persyaratan sediaan baik yaitu memiliki nilai floating lag time dalam rentang 5-600 detik dan floating duration time lebih dari 12 jam. Metode pembuatan yang paling banyak digunakan yaitu metode effervescent dengan penambahan polimer serta adanya agen effervescent yaitu reaksi antara natrium bikarbonat dengan asam organik (asam sistrat atau asam tartarat). Sediaan floating sustained release tablet mampu meningkatan nilai parameter farmakokinetik seperti t1/2, tmax dan peningkatan AUC dalam rentang 2,74-133,8 %.

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Floating drug delivery system: an outlook

Cited by 6 publications

References 11 publications

The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet

The Development of Alternative Dosage Form for Creatine Monohydrate: A Floating Tablet

Polymers used in mouth dissolving film: A review

Kajian Pengembangan Sediaan Floating Sustained Release Tablet

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