Mapping spatial data is essential for the monitoring of flooded areas, prognosis of hazards and prevention of flood risks. The Ganges River Delta, Bangladesh, is the world’s largest river delta and is prone to floods that impact social–natural systems through losses of lives and damage to infrastructure and landscapes. Millions of people living in this region are vulnerable to repetitive floods due to exposure, high susceptibility and low resilience. Cumulative effects of the monsoon climate, repetitive rainfall, tropical cyclones and the hydrogeologic setting of the Ganges River Delta increase probability of floods. While engineering methods of flood mitigation include practical solutions (technical construction of dams, bridges and hydraulic drains), regulation of traffic and land planning support systems, geoinformation methods rely on the modelling of remote sensing (RS) data to evaluate the dynamics of flood hazards. Geoinformation is indispensable for mapping catchments of flooded areas and visualization of affected regions in real-time flood monitoring, in addition to implementing and developing emergency plans and vulnerability assessment through warning systems supported by RS data. In this regard, this study used RS data to monitor the southern segment of the Ganges River Delta. Multispectral Landsat 8-9 OLI/TIRS satellite images were evaluated in flood (March) and post-flood (November) periods for analysis of flood extent and landscape changes. Deep Learning (DL) algorithms of GRASS GIS and modules of qualitative and quantitative analysis were used as advanced methods of satellite image processing. The results constitute a series of maps based on the classified images for the monitoring of floods in the Ganges River Delta.