This research investigates the application of logistic regression analysis for flood prone risk mapping in the Lam Se Bok watershed area. The study found that floods have occurred as many as 15 times since 2005. In 2019, flooding covered 200.01 km 2 of the watershed (5.51% of the total watershed). Among the areas that flood every year, 15 floods occurred in the lower part of the LSBW basin in Na Udom village, Khok Sawang and Fa Huan village, Rai Khi sub-district, which are in the south of Lue Amnat District, Amnat Charoen Province, as well as in parts of Dum Yai sub-district, Muang Sam Sip district, Ubon Ratchathani. Logistic regression analysis was used to determine the influence of certain variables on this flooding. The variables showing positive β values were mean annual precipitation and distance to a road. The variables showing negative β values included elevation, terrain, slope, soil drainage, distance to stream, land-use, and distance to village, respectively. All of these variables can be analyzed for their Flood Prone Risk area in GIS. The study found that floodprone areas at the very high-level flood prone risk areas, with a total area of 638.59 km 2 (17.59%), high level flood prone risk areas cover an area of 1,848.10 km2 (50.92%). Medium flood prone risk areas cover 794.95 km2 (21.90%). Low flood prone risk areas cover 310.86 km2 (8.56%), the least vulnerable to flooding encompassed 46.35 km2 (1.27%)., and occurred in areas with low elevation and areas with high annual average rainfall when the variable was located in the middle and downstream parts of the LSBW river basin.