Florid cutaneous papillomatosis leading to social exclusion

Csete, B; Moezzi, Medhi; Lengyel, Zsolt; Hodosi, B.; Zombai, E; Battyáni, Zita

doi:10.1111/j.1365-2133.2005.06772.x

Cited by 7 publications

(9 citation statements)

References 10 publications

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“…Histopathological findings include non-specific acanthoma with papillomatosis [10] – with incidental acantholysis present in two lesions, as reported by Schwartz and Burgess [11] – and no signs of dyskeratosis. Similar to our cases, familial dyskeratotic comedones are dyskeratotic cells at the bottom of comedo-like lesions [12].…”

Section: Discussionmentioning

confidence: 99%

Two Case Reports of Columnar Dyskeratosis, an Unusual Keratinisation Disorder

Pock¹,

Štork

2010

Dermatology

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Keratinisation disorders with distinctive histopathological patterns are few in number. We describe two men with unusual dermatosis, characterised by a distinctive pattern of focal dyskeratosis. Both men suffered from generalised dermatosis formed by verrucous red-brown plaques. Repeated skin biopsies showed the same histopathological pattern with foci of vertically oriented dyskeratotic cells. The dyskeratotic cells on the level of the stratum spinosum and granulosum were positive for AE1/AE3, CK-HW, CK-LS and CK116 immunostaining. PCR for HPV was negative. The similar clinical appearance of skin lesions in both patients together with their identical histopathological pictures seems to represent a unique clinicopathological condition that we believe is best described by the term ‘columnar dyskeratosis’.

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Section: Discussionmentioning

confidence: 99%

Two Case Reports of Columnar Dyskeratosis, an Unusual Keratinisation Disorder

Pock¹,

Štork

2010

Dermatology

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“…1 Lesions are clinically indistinguishable from viral papillomas, yet have no evidence of HPV infection. Florid cutaneous papillomatosis (FCP) is a rare condition characterized by the rapid onset of numerous warty papulonodules that may be widespread and result in facial disfigurement and social exclusion.…”

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confidence: 99%

Florid Cutaneous and Mucosal Papillomatosis: Mucocutaneous Markers of an Underlying Gastric Malignancy

Klieb

Avon

Gilbert

et al. 2013

JCO

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An 86-year female patient was referred to us for assessment of lip lesions and numerous cutaneous warty growths of 6-month duration. She had mild dysphagia but no systemic symptoms, including weight loss. Her only medication was risedronate for osteoporosis and she was otherwise healthy. Examination revealed confluent fine papillomatosis across the lip vermillion (Fig 1), which diffusely affected the mucosa of the oral cavity and oropharynx. There were several wartlike papules affecting the skin of her face, neck, and extremities (Fig 2). There was no cutaneous hyperpigmentation or velvety thickening.Histologic examination of cutaneous and mucosal lesions showed hyperkeratosis, acanthosis, and papillomatosis but no viral inclusion or vacuolar degeneration of keratinocytes. There was no evidence of human papillomavirus (HPV) by polymerase chain reaction. Results of complete blood count and serum chemistry were normal but tumor markers showed elevated carcinoembryonic antigen (19.3 ug/L; normal, 0 to 4 ug/L), which was suggestive of a gastrointestinal tract neoplasm. A computed tomography scan showed marked mural thickening of the gastric body and antrum and several enlarged, confluent upper abdominal lymph nodes. Upper gastrointestinal endoscopy revealed gastric mucosal friability and ulceration. Biopsies demonstrated a poorly differentiated carcinoma. Palliative measures were provided when the patient experienced a rapid deterioration in health, and she died after 3 months.The eruption of wart-like papules was suggestive of a viral genesis but, surprisingly, there was no evidence to support the presence of

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“…Every patient diagnosed with this condition has an underlying known or occult malignancy. The most commonly reported neoplasia is gastric adenocarcinoma [1][2][3][4][5][6][7][8][9][10][11][12]. However, it may occur in association with other intraabdominal malignancies, as well as lung or breast carcinoma and lymphoproliferative disorders [1-3, 10, 11].…”

Section: Case Discussionmentioning

confidence: 99%

“…Florid cutaneous papillomatosis (FCP) is a rare condition characterized by the abrupt appearance of numerous verrucous papules on the face, trunk, and extremities, that are morphologically identical to viral warts [1][2][3][4][5][6][7][8][9][10][11][12]. It is considered an obligatory paraneoplastic dermatosis, as it is always associated with an internal malignancy [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%