Florid, Papillary Endosalpingiosis of the Axillary Lymph Nodes

Stolnicu, Simona; Preda, Ovidiu; Kinga, Szabo; Marian, Cristina; Nicolau, Romeo; Andrei, Suciu Bogdan; Nicolae, Alina; Nogales, Francisco F.

doi:10.1111/j.1524-4741.2011.01081.x

Cited by 20 publications

(16 citation statements)

References 24 publications

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“…This has been aptly called the secondary Müllerian system (Lauchlan et al, 1994), which is not restricted to the peritoneum, but also present in the urinary bladder (Donne et al, 1998), ureter (Nogales et al, 1999), pleura and even in the abdominal and axillary lymph nodes (Stolnicu et al, 2011).…”

Section: Multifocal Peritoneal Metaplasia Induced By Growth Factorsmentioning

confidence: 99%

Gliomatosis peritonei as a natural experiment in tissue differentiation

Nogales¹,

Preda²,

Dulcey³

2012

Int. J. Dev. Biol.

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Gliomatosis peritonei (GP) is an unusual condition in which nodules of mature astroglia, often miliary and microscopic in size, are widespread in the peritoneum and abdominal lymph nodes. Its behaviour is benign and it is usually found in association with ovarian teratoma and rarely with teratomas of other organs. Implants grow rapidly and can remain unchanged for life. Astroglia is the main component, but other neural lineage elements and many other tissues can be found. Cells are mature but not terminal, since they express SOX2. Secondary associated lesions include: a) degenerative astrocytic changes, b) granulomatous and follicular chronic inflammatory changes, c) association with hormonally related changes, such as decidual peritoneal metaplasia and endometriosis and d) endothelial and adventitial vascular hyperplasia leading to haemoperitoneum. Two pathogenetic mechanisms are considered: direct seeding of immature neural cells from a primary tumour with subsequent differentiation and metaplasia from peritoneal stem cells. The former proposal is supported by clinicopathologic data such as ample cellular heterogeneity, coexistence of mature astroglia with neural blastema, as well as the shed keratin and hairs from the ovarian neoplasm. However, metaplasia is sustained by a heterozygosity pattern of GP nodules, identical to the normal tissue and different from the coexistent ovarian teratoma. GP would constitute a response to growth factors from teratoma or macrophages. While an implantative origin from ovarian teratoma remains in most cases a more probable mechanism, metaplasia from peritoneal stem cells would explain cases of GP which present a monomorphic astrocytic cell population.

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Section: Multifocal Peritoneal Metaplasia Induced By Growth Factorsmentioning

confidence: 99%

Gliomatosis peritonei as a natural experiment in tissue differentiation

Nogales¹,

Preda²,

Dulcey³

2012

Int. J. Dev. Biol.

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“…Immunohistochemistry would not be contributive in this case. Florid papillary endosalpingiosis of the axillary nodes has also been reported before [16]. Morphology—recognizing the absence of overt atypia—is crucial in establishing the correct diagnosis.…”

Section: Discussionmentioning

confidence: 71%

Axillary Metastasis from an Occult Tubal Serous Carcinoma in a Patient with Ipsilateral Breast Carcinoma: A Potential Diagnostic Pitfall

Atallah

Altinel

et al. 2014

Case Reports in Pathology

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Axillary nodal metastasis from a nonmammary neoplasia is much rarer than diseases associated with a primary breast carcinoma. However, this has to be considered in the differential diagnosis of nodal disease in patients with a history of breast cancer. Here, we report the case of a 73-year-old female with a past medical history of breast cancer, presenting with an ipsilateral axillary metastatic carcinoma. The immunohistochemical profile of the metastatic lesion was consistent with a high grade serous carcinoma. After undergoing a total abdominal hysterectomy and salpingo-oophorectomy, thorough pathological examination revealed two microscopic foci of serous carcinoma in the right fallopian tube, not detectable by preoperative magnetic resonance imaging. In this context, the poorly differentiated appearance of the metastatic tumor and positive staining for estrogen receptor, might lead to a misdiagnosis of metastatic breast carcinoma. As the therapeutic implications differ, it is important for the pathologist to critically assess axillary lymph node metastases, even in patients with a past history of ipsilateral breast carcinoma and no other known primary tumors.

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“…Psammoma bodies, as seen in our case, have also been reported. 2,10 For benign lesions, the lymph node inclusion should morphologically be distinct from the primary lesion, may possess a myoepithelial layer, and lack marked cellular and architectural atypia, necrosis, and desmoplasia 1 ( Table 2). At times the identification of a basement membrane 4 may help to confirm the benign nature of the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…At times the complete resemblance to that of the fallopian tube is not complete, with lack of intercolated cells and cilia, therefore the term "serous change," has also been reported. 2 Endosalpingiosis is commonly encountered in pelvic retroperitoneal lymph nodes, with an incidence of 11.4% in woman undergoing lymph node evaluation in association with radical hysterectomy performed for cervical carcinoma. 12 The finding of endosalpingiosis involving lymph nodes occurring outside of these regions and above the diaphragm is an extremely rare event.…”

Section: Discussionmentioning

confidence: 99%

Coexistent Isolated Tumor Cell Clusters of Infiltrating Lobular Carcinoma and Benign Glandular Inclusions of Müllerian (Endosalpingiosis) Type in an Axillary Sentinel Node

Groth

Prabhu

Wiley³

2016

Applied Immunohistochemistry &Amp; Molecular Morphology

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The presence of benign epithelial inclusions in axillary lymph nodes coexistant with breast disease is a rare event; however, their presence makes the assessment of nodal disease diagnostically challenging. Broadly, these inclusions can be classified as glandular (müllerian type or nonmüllerian type), mixed glandular-squamous, and squamous. Among these the presence of benign müllerian-type glandular inclusions with concurrent breast parenchymal disease is an exceedingly rare event, with 10 previous cases reported in the literature, 2 coexisting with infiltrating ductal-type mammary carcinoma in axillary lymph nodes. Here, we report the first case of coexistent invasive lobular carcinoma and endosalpingiosis in an axillary lymph node.

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Florid, Papillary Endosalpingiosis of the Axillary Lymph Nodes

Cited by 20 publications

References 24 publications

Gliomatosis peritonei as a natural experiment in tissue differentiation

Gliomatosis peritonei as a natural experiment in tissue differentiation

Axillary Metastasis from an Occult Tubal Serous Carcinoma in a Patient with Ipsilateral Breast Carcinoma: A Potential Diagnostic Pitfall

Coexistent Isolated Tumor Cell Clusters of Infiltrating Lobular Carcinoma and Benign Glandular Inclusions of Müllerian (Endosalpingiosis) Type in an Axillary Sentinel Node

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