Although Hypochaeris radicata L. is a noxious alien species in Korea, there is no effective way to prevent it from spreading. Therefore, this study aims to study the possibility of using H. radicata as an effective natural compound source which will contribute to the utilization of the invasive alien species and some extent to prevent invasion. Hot water and ethanol extracts of H. radicata showed high efficiency as a natural antioxidant indicating the species may be used as a natural antioxidant material. Extracts of H. radicata has shown no toxic effects on cells. Rather, H. radicata extract has an function of inhibiting the generation of NO in high concentrations of extracts which means that H. radicata extract has a function of anti-inflammatory effect. When the research on the effect of H. radicata finds out more, the utilization of this species will be increased and the environmentally friendly public participation management will be possible due to an increase in its collection. Also, it is meaningful that we have attempted to find an ecological engineering approach through utilization methods of alien species that has been spread widely in Korea.