2014
DOI: 10.1371/journal.pone.0086117
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Flos Lonicera Ameliorates Obesity and Associated Endotoxemia in Rats through Modulation of Gut Permeability and Intestinal Microbiota

Abstract: Background and AimIncreasing evidence has indicated a close association of host-gut flora metabolic interaction with obesity. Flos Lonicera, a traditional herbal medicine, is used widely in eastern Asia for the treatment of various disorders. The aim of this study was to evaluate whether unfermented or fermented formulations of Flos Lonicera could exert a beneficial impact to combat obesity and related metabolic endotoxemia.MethodsObesity and metabolic endotoxemia were induced separately or together in rats th… Show more

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Cited by 87 publications
(87 citation statements)
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“…fiber, 42 g/kg diet) and tap water ad libitum. 37 To investigate the effects of 1 in vivo, mice were randomly assigned to six groups: a control group (water), an LPS-treated group (5 mg/kg), and four LPS-and 1-treated groups.…”
Section: ■ Experimental Sectionmentioning
confidence: 99%
“…fiber, 42 g/kg diet) and tap water ad libitum. 37 To investigate the effects of 1 in vivo, mice were randomly assigned to six groups: a control group (water), an LPS-treated group (5 mg/kg), and four LPS-and 1-treated groups.…”
Section: ■ Experimental Sectionmentioning
confidence: 99%
“…The optimized annealing temperature of the primers was 60°C. The standard conditions for the PCR amplification reactions were applied as previously described [19]. LightCycler software (Roche Applied Science) was used for analysis.…”
Section: Preparation Of Genomic Dna From Fecal Samplesmentioning
confidence: 99%
“…This is again due to the fact that microbes are always competing for dominance, which leads to problems such as irritable bowel syndrome, eczema, certain diseases, and even allergies (Abrahamsson et al, 2012;Azad et al, 2013;Bolino and Bercik, 2010;Cani et al, 2008;Forno et al, 2009;Gratz et al, 2010). An individual's microbiota will then affect their adiposity, inflammation, immune system, metabolism, energy, hypertension, and even gut permeability, which would explain how gut bacteria are found within tumors in the first place (Abou-Donia et al, 2008;Bolino and Bercik, 2010;Cani and Delzenne, 2009;Cani and Delzenne, 2010;Cani et al, 2008;DiBaise et al, 2008;Hugot, 2004;Iwamoto et al, 2010;Kadooka et al, 2010;Kirjavainen et al, 1999;Kruis et al, 1991;Leyer et al, 2009;Lye et al, 2009;Majamaa and Isolauri, 1997;Mcfarland and Bernasconi, 1993;Rao et al, 2009;Selvam et al, 2009;Soler et al, 1999;Sullivan et al, 2009;Wang et al, 2014). The correlation between nutrition, the microbiome, and cancer is most significantly illustrated in western society where obesity is one of the leading causes of cancer in nonsmokers with liver disease being the largest cancer risk for individuals above 35 BMI (Calle and Kaaks, 2004;Calle and Thun, 2004).…”
Section: Effects Of Nutrition and Radioprotectants On The Microbiomementioning
confidence: 99%
“…Even the lung tumors of smokers has considerable association with microbes as well (Cummins and Tangney, 2013). The microbiome has also been shown to secrete metabolites that promote liver cancer through the senescence secretome (Cani and Delzenne, 2010;DiBaise et al, 2008;Kadooka et al, 2010;Pischon et al, 2008;Wang et al, 2014;Yoshimoto et al, 2013).…”
Section: Effects Of Nutrition and Radioprotectants On The Microbiomementioning
confidence: 99%