Along with the accompanying theory article, we experimentally investigate the effect of the depletion attraction force on the flotation of malachite. While varying the concentration of the depletion agent (polyethylene glycol), three different systems are studied: pure malachite, pure silica and a 1:1 mass ratio of malachite and silica binary system. We find that the recovery increases significantly as the concentration of the depletion reagents increases for all three systems. However, the recovery suddenly decreases in a certain concentration range, which corresponds to the onset of the decreased surface tension when high concentrations of the depletion agent are used. The decreased surface tension of the air/water interface suggests that the recovery rate is lowered due to the adsorption of the depletion agent to the bubble surface, acting as a polymer brush. We also perform experiments in the presence of a small amount of a collector, sodium oleate. An extremely small amount of the collector (10−10–10−5 M) leads to the increase in the overall recovery, which eventually reaches nearly 100 percent. Nevertheless, the grade worsens as the depletant provides the force to silica particles as well as target malachite particles.