During its life cycle, packaging comes into contact with various substances and even those it protects. Thus, for example, oil, water, and alcohol, if spilled on the packaging, can damage its functionality. In addition to exposure to chemicals, graphic products (packaging) can be exposed to moisture and UV radiation, which can negatively affect their stability during transport, storage, and handling. The choice of printing substrate can directly affect the stability of prints against different degrading influences. This paper explores the stability of thermochromic (TC) and conventional offset printing inks printed on environmentally friendly printing substrates intended for packaging applications (labelling). Results have confirmed that used printing substrates and printing inks give prints good rub resistance, but somewhat lower stability in terms of ethanol, water, and UV radiation. The choice of printing substrate can directly affect the stability of prints against different degrading influences. The resistance of prints to oil cannot be clearly defined since the samples were altered with the coloration of the oil. It can only be stated that oil reduced the functionality of the TC prints given that the samples were colored by the oil itself.