Flourensia fiebrigii S.F. blake: A medicinal plant from the Argentinean highlands with potential use as anti-rheumatic and anti-inflammatory

Leal, Mariana; Zampini, Iris Catiana; Mercado, María Inés; Moreno, María Alejandra; Simirgiotis, Mario J.; Bórquez, Jorge; Ponessa, Graciela I.; Isla, Marı́a Inés

doi:10.1016/j.jep.2020.113296

Cited by 6 publications

(9 citation statements)

References 35 publications

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“…The roles of exudates in plants are diverse and include defence against pests and diseases and allelopathic activity [18] . Bioactive compounds are stored in the cuticular sacs of mature trichomes and released to the leaf surface [8,19] . Our study also observed glandular trichomes on the adaxial and abaxial leaf surfaces (Figure 1).…”

Section: Resultssupporting

confidence: 55%

“…[18] Bioactive compounds are stored in the cuticular sacs of mature trichomes and released to the leaf surface. [8,19] Our study also observed glandular trichomes on the adaxial and abaxial leaf surfaces (Figure 1).…”

Section: Phytochemical Compositionsupporting

confidence: 68%

“…Some compounds include flavonoids, some of them are prenylated flavonoids such as 8-prenyleriodictyol and 5,3-dihydroxyisobavachin-7-O-methyl ether, phenolic compounds (piceol), benzofurans like tremetone, 6methoxytremetone, 2-isopropenyl-3-oxyangeloyl-5-acetyl-cis-2,3-dihydrobenzofuran, and phytotoxic sesquiterpene (À )-hamanasic acid A, and 7-carboxy-8-hydroxy-1(2), 12(13)-dienbisabolene. [4][5][6][7][8][9] Many of them show antibacterial activities against human pathogenic bacteria. [5,9] Food-borne pathogenic bacteria are the significant public health concerns worldwide, affecting food safety and causing human illness due to consuming foodstuffs contaminated with vegetative pathogens or their toxins.…”

Section: Introductionmentioning

confidence: 99%

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UHPLC‐MS/MS and GC‐MS Metabolic Profiling of a Medicinal Flourensia Fiebrigii Chemotype

Verni,

Matos,

Alberto

et al. 2024

Chemistry & Biodiversity

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The comparative metabolic profiling and their biological properties of eight extracts obtained from diverse parts (leaves, flowers, roots) of the medicinal plant Flourensia fiebrigii S.F. Blake, a chemotype growing in highland areas (2750 m a.s.l.) of northwest Argentina, were investigated. The extracts were analysed by GC‐MS and UHPLC‐MS/MS. GC‐MS analysis revealed the presence of encecalin (relative content: 24.86%) in ethereal flower extract (EF) and this benzopyran (5.93%) together sitosterol (11.35%) in the bioactive ethereal leaf exudate (ELE). By UHPLC‐MS/MS the main compounds identified in both samples were: limocitrin, (22.31%), (2Z)‐4,6‐dihydroxy‐2‐[(4‐hydroxy‐3,5‐dimethoxyphenyl)methylidene]‐1‐benzofuran‐3‐one (21.31%), isobavachin (14.47%), naringenin, (13.50%), and sternbin, (12.49%). Phytocomplexes derived from aerial parts exhibited significant activity against biofilm production of Pseudomonas aeruginosa and Staphylococcus aureus, reaching inhibitions of 74.7–99.9% with ELE (50 µg/mL). Notably, the extracts did not affect nutraceutical and environmental bacteria, suggesting a selective activity. ELE also showed the highest reactive species scavenging ability. This study provides valuable insights into the potential applications of this chemotype.

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Section: Resultssupporting

confidence: 55%

Section: Phytochemical Compositionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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UHPLC‐MS/MS and GC‐MS Metabolic Profiling of a Medicinal Flourensia Fiebrigii Chemotype

Verni,

Matos,

Alberto

et al. 2024

Chemistry & Biodiversity

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“…15 Many species of this family, and particularly within the tribe, are widely used in folk medicine as anti-asthmatic, digestive, emmenagogue, vulnerary, diaphoretic, antispasmodic, antialopecic, insecticides, parasiticides, anti-inflammatory, anti-rheumatic and antifungal. [16][17][18][19] From the phytochemical perspective, only a few compounds in this tribe's species have been reported, including flavonoids, monoterpenes, sesquiterpenes, and furanocoumarins (FCs). [20][21][22][23][24][25][26] Chemically speaking, the Asteraceae plant family has been relatively poorly studied as a potential natural source of photosensitizers.…”

Section: Introductionmentioning

confidence: 99%

“…This extensive family includes 13 tribes (sensu Bentham & Hooker, 1873), among which the Mutisieae tribe is one of the most represented in Argentinian flora 15 . Many species of this family, and particularly within the tribe, are widely used in folk medicine as anti‐asthmatic, digestive, emmenagogue, vulnerary, diaphoretic, antispasmodic, antialopecic, insecticides, parasiticides, anti‐inflammatory, anti‐rheumatic and antifungal 16–19 . From the phytochemical perspective, only a few compounds in this tribe's species have been reported, including flavonoids, monoterpenes, sesquiterpenes, and furanocoumarins (FCs) 20–26 .…”

Section: Introductionmentioning

confidence: 99%

Extracts of Trichocline sinuata (Asteraceae) as natural sensitizers in the photodynamic inactivation of Candida albicans

Schiavi,

Svetaz,

Petenatti

et al. 2023

Photochem & Photobiology

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Despite significant progress in the development of phototherapy drugs, it is widely recognized that natural products remain the primary source of new photoactive compounds. Exploring uncharted flora in the east‐central region of Argentina may offer a vast array of opportunities to isolate new photoactive molecules or plant extracts with high potential for use in antimicrobial photodynamic therapy (aPDT) against Candida albicans. To assess the photofungicidal potential of T. sinuata (“contrayerba”) against C. albicans, the extracts underwent spectroscopic and chromatographic analysis, resulting in the identification of furanocoumarin metabolites with similar spectrophotometric properties in all extracts. The extract profiles were created using UHPLC‐DAD, and seven furanocoumarins (FCs) were detected. The highest photoinactivation against C. albicans was observed for dicholormethanic extracts (MFC = 62.5 μg/mL), equal to xanthotoxin employed as a positive control. Furthermore, we determine that photochemical mechanisms dependent on oxygen (type I and type II processes) and mechanisms independent of oxygen (photoadduct formation) are involved in the death of these yeasts. These results support the use of native plants of the east‐central region of Argentina as potent sensitizers for aPDT and suggest that they can replace xanthotoxin in treating superficial yeast infections of the skin.

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Metabolomics and Genomics for Understanding Stress Biology of Plant Metabolites

Kashyap¹,

Shah²,

Pant³

et al. 2022

Phytochemical Genomics

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Flourensia fiebrigii S.F. blake: A medicinal plant from the Argentinean highlands with potential use as anti-rheumatic and anti-inflammatory

Cited by 6 publications

References 35 publications

UHPLC‐MS/MS and GC‐MS Metabolic Profiling of a Medicinal Flourensia Fiebrigii Chemotype

UHPLC‐MS/MS and GC‐MS Metabolic Profiling of a Medicinal Flourensia Fiebrigii Chemotype

Extracts of Trichocline sinuata (Asteraceae) as natural sensitizers in the photodynamic inactivation of Candida albicans

Metabolomics and Genomics for Understanding Stress Biology of Plant Metabolites

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