This paper presents an experiment of flow control by supersonic pulsed jets in a very aggressive S-duct typical of modern fighter aircraft engine inlet ducts. The Mach number in the aerodynamic interface plane ranges from 0.2 to 0.4, which is realistic from an application point of view. It was shown that, with continuous blowing, the flow could be fully reattached. The sensitivity of the distortion coefficient to the jet frequency was also clearly evidenced. Surprisingly, it is recommended to avoid actuating the jets at the natural frequencies present in the separated zone of the uncontrolled flow. Besides, it is observed that pulsed jets actuation increases the unsteady flow distortion. Furthermore, in the uncontrolled flow, a lateral movement of the structures associated with high total pressure losses in the aerodynamic interface plane was highlighted. Nomenclature c = velocity of sound, m∕s D 1 = inflow section diameter, mm D 2 = exit section diameter, mm d = jet diameter, mm d a = average duct diameter, mm Ef = spectral density of power, Pa 2 ∕Hz f = frequency, Hz H = offset of the outlet section with respect to the inflow section, mm L = jet stroke length, m L duct = distance from the bell mouth to the translating plug, mm L sep = separation length estimated from the pressure distribution, mm Ma = averaged Mach number in the aerodynamic interface plane Ma 1= isentropic Mach number in the inflow section P dyn = dynamic pressure in the inflow section, Pa Pi = stagnation pressure in the aerodynamic interface plane, Pa Pi 0 = external atmospheric stagnation pressure, Pa Ps 1 = inlet static pressure, Pa Q d = duct mean mass flow rate, g∕s Q dyn = dynamic pressure in the aerodynamic interface plane, Pa Q j = total jet mean mass flow rate, g∕s T = forcing period, s (t, r, n) = frame of reference local to the jets U 1 = velocity in the inflow section, m∕s x, y, z = longitudinal, vertical, and spanwise directions (respectively), mm α = jet pitch angle, deg β = jet skew angle, deg η = duct mean efficiency Φ = angle along the duct circumference, deg <> = operator that denotes an averaging on the 40 pressure sensors in the aerodynamic interface plane