Flow cytometric nuclear DNA analysis in resected primary adenocarcinoma of the lung and applications to prognosis and adjuvant chemotherapy

Yamaoka, Norio; Uchiyama, Yoshitaka; Taniguchi, Hideki; Morinaga, Masafumi; Yamasaki, Naoya

doi:10.2995/jacsurg1987.5.498

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“…Given an aneuploid to diploid tumour ratio of 8:2 (Yamaoka et al, 1991), 80% of stage I, II, and III cases were estimated to be aneuploid. The required number of cases was therefore estimated to be 212 cases of stage I disease and 128 cases of stage II or III disease.…”

Section: Discussionmentioning

confidence: 99%

Randomised study of adjuvant chemotherapy for completely resected p-stage I–IIIA non-small cell lung cancer

et al. 2006

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We evaluated the therapeutic usefulness of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). We also examined the relation between DNA ploidy pattern and the response to chemotherapy. A total of 267 patients with NSCLC (pathologically documented stage I, II, or IIIA) underwent complete resection, and DNA ploidy pattern was analysed. Patients with stage I disease (n ¼ 172) were randomly assigned to receive surgery alone (group A) or surgery followed by adjuvant chemotherapy (UFT (oral anti-cancer drug, a combination of Uracil and Tegaful) 400 mg day À1 for 1 year after surgery; group B). Stage II or IIIA disease patients (n ¼ 95) were randomly assigned to surgery alone (group C) or surgery followed by chemotherapy (two 28-day courses of cisplatin 80 mg m À2 on day 1 plus vindesine 3 mg m À2 on days 1 and 8, followed by UFT 400 mg day À1 for at least 1 year; group D). Eight-year overall survival rate in patients with stage I disease was 74.2% (95% confidence interval (CI): 64.4 -84.0%) in group B and 57.6% (95% CI: 46.4 -68.8%) in group A (P ¼ 0.045 by log-rank test). In patients with stage II and IIIA disease, no difference was found between groups C and D. Analysis according to DNA ploidy pattern revealed no difference between the groups. Postoperative chemotherapy with UFT was suggested to be useful in patients with completely resected stage I NSCLC. No difference was seen in relation to DNA pattern in any treatment group.

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Section: Discussionmentioning

confidence: 99%