When the ultra-high-speed elevator car-counterweight system runs opposite each other, significant piston effects are caused, seriously affecting the elevator operation's stability. In order to explore the aerodynamic characteristics of the whole operation process of a car-counterweight system under multi-parameters, this study first establishes a three-dimensional transient model of the car-counterweight system and a multi-region dynamic layering numerical simulation method based on this model is proposed. Then, the actual elevator experiment validates the correctness of the model and the method. Finally, the influence rules of key parameters on the car's aerodynamic characteristics and ventilation effect are analyzed, and the car's aerodynamic characteristics at intersection time are analyzed emphatically. The results show that with the increase in the blocking ratio, the pressure drag and viscous drag have similar change trends at each stage, but the influence of pressure drag is more significant. The air displacement ratio increases by 34.1%, 75.8%, and 117.3%, respectively. With the increase in the hoistway height, the air displacement ratio decreases by 0.9%, 2.4%, and 2.9%, respectively. The spacing significantly affects the car's aerodynamic characteristics at the intersection time. The drag peak increases by 6.8%, 13.6%, and 20.5% and the lift peak by 21.2%, 47.8%, and 82.5%, respectively.