A prefabricated pumping station is a new type of pumping station that plays an important role in the construction of sponge cities in developing countries. It solves the problem of urban water-logging and makes great contributions to the sustainable development of water resources. In order to research the influence of different installation positions of pumps on the internal hydraulic performance of a prefabricated pumping station, based on ANSYS software, the computational fluid dynamics (CFD) numerical simulation method was used to analyze the internal flow state of the prefabricated pump station. In this research, the optimal geometric parameters of pump installation in a prefabricated pumping station are given. The results show that when the distance between the connecting line of two pumps and the center of the sump is L = 0.2 R, the distance between the two pumps is S = 0.6 R, and the suspension height of the two pumps is H = 0.6 D, the internal flow pattern of the prefabricated pump station is better. (R is the cross-sectional radius of the sump and D is the diameter of the nozzle of the pump horn.) These research results have certain guiding significance for improvement of the hydraulic performance and operation efficiency of prefabricated pump stations. They also provide a theoretical basis for parameter selection for prefabricated pumping stations.